{"title":"蛙肝微粒体月桂酸羟化酶活性的季节变化和性别差异。","authors":"Y Miura","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The content of cytochrome P-450 and the specific activity of laurate hydroxylation have been measured at monthly intervals through the year in liver microsomes of males and females of Japanese bullfrog, Rana catesbeiana. The specific activity, based on microsomal protein or cytochrome P-450 of both sexes was higher in spring (April-May) than in autumn (October-November) and the difference was statistically significant. However, in males the content of the cytochrome P-450 in the spring was almost the same level as in the autumn and it was rather lower in the spring than in the autumn in females. These suggest that the cytochrome P-450 species catalyzing laurate hydroxylation increased specifically in the spring. The specific activity (based on cytochrome P-450) in males was significantly higher than that in females in spring (April-May) or autumn (October-November).</p>","PeriodicalId":10579,"journal":{"name":"Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology","volume":"82 1","pages":"63-7"},"PeriodicalIF":0.0000,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Seasonal change and sex difference in laurate hydroxylase activity in frog liver microsomes.\",\"authors\":\"Y Miura\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The content of cytochrome P-450 and the specific activity of laurate hydroxylation have been measured at monthly intervals through the year in liver microsomes of males and females of Japanese bullfrog, Rana catesbeiana. The specific activity, based on microsomal protein or cytochrome P-450 of both sexes was higher in spring (April-May) than in autumn (October-November) and the difference was statistically significant. However, in males the content of the cytochrome P-450 in the spring was almost the same level as in the autumn and it was rather lower in the spring than in the autumn in females. These suggest that the cytochrome P-450 species catalyzing laurate hydroxylation increased specifically in the spring. The specific activity (based on cytochrome P-450) in males was significantly higher than that in females in spring (April-May) or autumn (October-November).</p>\",\"PeriodicalId\":10579,\"journal\":{\"name\":\"Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology\",\"volume\":\"82 1\",\"pages\":\"63-7\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1985-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Seasonal change and sex difference in laurate hydroxylase activity in frog liver microsomes.
The content of cytochrome P-450 and the specific activity of laurate hydroxylation have been measured at monthly intervals through the year in liver microsomes of males and females of Japanese bullfrog, Rana catesbeiana. The specific activity, based on microsomal protein or cytochrome P-450 of both sexes was higher in spring (April-May) than in autumn (October-November) and the difference was statistically significant. However, in males the content of the cytochrome P-450 in the spring was almost the same level as in the autumn and it was rather lower in the spring than in the autumn in females. These suggest that the cytochrome P-450 species catalyzing laurate hydroxylation increased specifically in the spring. The specific activity (based on cytochrome P-450) in males was significantly higher than that in females in spring (April-May) or autumn (October-November).
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