昆虫中枢神经系统中DDT和狄氏剂作用的胆碱能机制。

Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology Pub Date : 1985-01-01

Y Morio, K Takeno, O Yagasaki, I Yanagiya

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引用次数: 0

摘要

采用腹腔第六神经节研究了DDT和狄氏剂对蟑螂胆碱能神经传递的影响。细胞外电极记录的神经节自发放电增加0.1 mM滴滴涕和1微米狄氏剂。这种刺激作用被0.5 mM d-管curarine和0.1 mM的hemicholium -3部分阻断，在高Mg2+-低Ca2+的介质中消失。DDT和狄氏剂均能增加神经节中乙酰胆碱的释放和含量。这些结果表明滴滴涕和狄氏剂都能刺激乙酰胆碱的释放和合成。

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Involvement of the cholinergic mechanism in DDT and dieldrin action in the insect central nervous system.

The effects of DDT and dieldrin on cholinergic neurotransmission were studied using the sixth abdominal ganglion of the cockroach. Spontaneous electrical discharges in the ganglion recorded with an extracellular electrode were augmented by 0.1 mM DDT and 1 microM dieldrin. This stimulating action was partly blocked by 0.5 mM d-tubocurarine and 0.1 mM hemicholinium-3 and disappeared in a high Mg2+-low Ca2+ medium. DDT and dieldrin increased both ACh release and ACh content in the ganglion. These results suggested that DDT and dieldrin stimulate both ACh release and synthesis.

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Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology

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