{"title":"了解高剪切湿法造粒预混合中混合性能与功耗之间的关系","authors":"Zeng Liu, Chunling Liu, Renyu Fan, Yuting Wang, Linxiu Luo, Yanling Jiang, Jincao Tang, Zheng Lu, Libo Chen, Shuangkou Chen, Tianbing Guan, Chuanyun Dai","doi":"10.1007/s12247-024-09816-y","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><p>High-shear wet granulation (HSWG) is most commonly used in the pharmaceutical industry, with the advantages of being fully enclosed, having a good mixing effect, and being highly efficient. However, only a few studies are geared toward an in-depth understanding of the pre-mixing process in the high-shear wet granulator (HSWGr).</p><h3>Objectives</h3><p>In this paper, the effect of impeller speed and fill level on the mixing performance of particles is investigated using the discrete element method (DEM), which provides theoretical references for the energy-saving operation in HSWGr.</p><h3>Methods</h3><p>Relative standard deviation (RSD) was used as a mixing index to quantify mixing quality, particle temperature over a vertical distance to quantify particle motion bias, and total power consumption per unit mass to monitor the loss effect.</p><h3>Results</h3><p>The simulation results show that the impeller speed only affects the mixing process and does not change the mixing uniformity; the fill level has a significant effect on the particle mixing, and a higher fill level will inhibit the particle mixing; based on the uniform mixing, the fill level has little effect on the total power consumption per unit mass.</p><h3>Conclusion</h3><p>The results of the study show that increasing the fill level and impeller speed contributes to the energy-saving operation of HSWGr.</p></div>","PeriodicalId":656,"journal":{"name":"Journal of Pharmaceutical Innovation","volume":"19 2","pages":""},"PeriodicalIF":2.7000,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"An Understanding of the Relationship Between Mixing Performance and Power Consumption in a High-Shear Wet Granulation Pre-mixing\",\"authors\":\"Zeng Liu, Chunling Liu, Renyu Fan, Yuting Wang, Linxiu Luo, Yanling Jiang, Jincao Tang, Zheng Lu, Libo Chen, Shuangkou Chen, Tianbing Guan, Chuanyun Dai\",\"doi\":\"10.1007/s12247-024-09816-y\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Introduction</h3><p>High-shear wet granulation (HSWG) is most commonly used in the pharmaceutical industry, with the advantages of being fully enclosed, having a good mixing effect, and being highly efficient. However, only a few studies are geared toward an in-depth understanding of the pre-mixing process in the high-shear wet granulator (HSWGr).</p><h3>Objectives</h3><p>In this paper, the effect of impeller speed and fill level on the mixing performance of particles is investigated using the discrete element method (DEM), which provides theoretical references for the energy-saving operation in HSWGr.</p><h3>Methods</h3><p>Relative standard deviation (RSD) was used as a mixing index to quantify mixing quality, particle temperature over a vertical distance to quantify particle motion bias, and total power consumption per unit mass to monitor the loss effect.</p><h3>Results</h3><p>The simulation results show that the impeller speed only affects the mixing process and does not change the mixing uniformity; the fill level has a significant effect on the particle mixing, and a higher fill level will inhibit the particle mixing; based on the uniform mixing, the fill level has little effect on the total power consumption per unit mass.</p><h3>Conclusion</h3><p>The results of the study show that increasing the fill level and impeller speed contributes to the energy-saving operation of HSWGr.</p></div>\",\"PeriodicalId\":656,\"journal\":{\"name\":\"Journal of Pharmaceutical Innovation\",\"volume\":\"19 2\",\"pages\":\"\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2024-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Pharmaceutical Innovation\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s12247-024-09816-y\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Pharmaceutical Innovation","FirstCategoryId":"3","ListUrlMain":"https://link.springer.com/article/10.1007/s12247-024-09816-y","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
An Understanding of the Relationship Between Mixing Performance and Power Consumption in a High-Shear Wet Granulation Pre-mixing
Introduction
High-shear wet granulation (HSWG) is most commonly used in the pharmaceutical industry, with the advantages of being fully enclosed, having a good mixing effect, and being highly efficient. However, only a few studies are geared toward an in-depth understanding of the pre-mixing process in the high-shear wet granulator (HSWGr).
Objectives
In this paper, the effect of impeller speed and fill level on the mixing performance of particles is investigated using the discrete element method (DEM), which provides theoretical references for the energy-saving operation in HSWGr.
Methods
Relative standard deviation (RSD) was used as a mixing index to quantify mixing quality, particle temperature over a vertical distance to quantify particle motion bias, and total power consumption per unit mass to monitor the loss effect.
Results
The simulation results show that the impeller speed only affects the mixing process and does not change the mixing uniformity; the fill level has a significant effect on the particle mixing, and a higher fill level will inhibit the particle mixing; based on the uniform mixing, the fill level has little effect on the total power consumption per unit mass.
Conclusion
The results of the study show that increasing the fill level and impeller speed contributes to the energy-saving operation of HSWGr.
期刊介绍:
The Journal of Pharmaceutical Innovation (JPI), is an international, multidisciplinary peer-reviewed scientific journal dedicated to publishing high quality papers emphasizing innovative research and applied technologies within the pharmaceutical and biotechnology industries. JPI''s goal is to be the premier communication vehicle for the critical body of knowledge that is needed for scientific evolution and technical innovation, from R&D to market. Topics will fall under the following categories:
Materials science,
Product design,
Process design, optimization, automation and control,
Facilities; Information management,
Regulatory policy and strategy,
Supply chain developments ,
Education and professional development,
Journal of Pharmaceutical Innovation publishes four issues a year.