了解高剪切湿法造粒预混合中混合性能与功耗之间的关系

IF 2.7 4区 医学 Q2 PHARMACOLOGY & PHARMACY
Zeng Liu, Chunling Liu, Renyu Fan, Yuting Wang, Linxiu Luo, Yanling Jiang, Jincao Tang, Zheng Lu, Libo Chen, Shuangkou Chen, Tianbing Guan, Chuanyun Dai
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引用次数: 0

摘要

摘要 引言 高剪切湿法制粒(HSWG)最常用于制药行业,具有全封闭、混合效果好、效率高等优点。然而,深入了解高剪切湿法制粒机(HSWGr)预混合过程的研究却寥寥无几。 本文采用离散元法(DEM)研究了叶轮转速和填充水平对颗粒混合性能的影响,为 HSWGr 的节能运行提供理论参考。 方法 采用相对标准偏差(RSD)作为混合指标来量化混合质量,采用垂直距离上的颗粒温度来量化颗粒运动偏差,采用单位质量的总功耗来监测损耗效应。 结果 模拟结果表明,叶轮转速只影响混合过程,不会改变混合均匀度;填充水平对颗粒混合有显著影响,填充水平越高,颗粒混合越受抑;在混合均匀的基础上,填充水平对单位质量总功耗影响不大。 结论 研究结果表明,提高填充量和叶轮转速有助于 HSWGr 的节能运行。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
An Understanding of the Relationship Between Mixing Performance and Power Consumption in a High-Shear Wet Granulation Pre-mixing

Introduction

High-shear wet granulation (HSWG) is most commonly used in the pharmaceutical industry, with the advantages of being fully enclosed, having a good mixing effect, and being highly efficient. However, only a few studies are geared toward an in-depth understanding of the pre-mixing process in the high-shear wet granulator (HSWGr).

Objectives

In this paper, the effect of impeller speed and fill level on the mixing performance of particles is investigated using the discrete element method (DEM), which provides theoretical references for the energy-saving operation in HSWGr.

Methods

Relative standard deviation (RSD) was used as a mixing index to quantify mixing quality, particle temperature over a vertical distance to quantify particle motion bias, and total power consumption per unit mass to monitor the loss effect.

Results

The simulation results show that the impeller speed only affects the mixing process and does not change the mixing uniformity; the fill level has a significant effect on the particle mixing, and a higher fill level will inhibit the particle mixing; based on the uniform mixing, the fill level has little effect on the total power consumption per unit mass.

Conclusion

The results of the study show that increasing the fill level and impeller speed contributes to the energy-saving operation of HSWGr.

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来源期刊
Journal of Pharmaceutical Innovation
Journal of Pharmaceutical Innovation PHARMACOLOGY & PHARMACY-
CiteScore
3.70
自引率
3.80%
发文量
90
审稿时长
>12 weeks
期刊介绍: The Journal of Pharmaceutical Innovation (JPI), is an international, multidisciplinary peer-reviewed scientific journal dedicated to publishing high quality papers emphasizing innovative research and applied technologies within the pharmaceutical and biotechnology industries. JPI''s goal is to be the premier communication vehicle for the critical body of knowledge that is needed for scientific evolution and technical innovation, from R&D to market. Topics will fall under the following categories: Materials science, Product design, Process design, optimization, automation and control, Facilities; Information management, Regulatory policy and strategy, Supply chain developments , Education and professional development, Journal of Pharmaceutical Innovation publishes four issues a year.
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