通过 UPLC-MS/MS 测定大鼠血浆中紫玉糖苷 I 和紫玉糖苷 II 的药代动力学

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-03-01 DOI:10.1155/2024/7971021

Xiuwei Shen, Ziyue Wang, Wenting Li, Shenshen Mei, Shunjun Ma, Xianqin Wang, Congcong Wen, Fan Chen, Guojun Zheng

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引用次数: 0

摘要

紫玉糖苷 I 和紫玉糖苷 II 是山银花的重要活性成分，具有很好的药理作用，如抗氧化和抗癌作用。然而，关于紫杉糖苷 I 和紫杉糖苷 II 的生物利用度尚未见报道。本研究旨在建立一种 UPLC-MS/MS 方法，以研究不同给药途径（胃内给药和静脉给药）下紫玉糖苷 I 和紫玉糖苷 II 在大鼠体内的药代动力学，并计算其生物利用度。大鼠血浆中齐尤甙 I 和齐尤甙 II 的浓度在 2-2000 纳克/毫升范围内呈良好的线性关系（r > 0.99）。ziyuglycoside I 和 ziyuglycoside II 的日内准确度为 87% 至 110%，日间准确度为 97% 至 109%。日内精确度低于 15%，日间精确度低于 14%。基质效应为 88% 至 113%。回收率均高于 84%。应用所建立的 UPLC-MS/MS 方法测定了大鼠血浆中齐尤糖苷 I 和齐尤糖苷 II 的药代动力学。结果表明，紫杉甙 I 和紫杉甙 II 的生物利用度分别为 2.6% 和 4.6%。

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Pharmacokinetics of Ziyuglycoside I and Ziyuglycoside II in Rat Plasma by UPLC-MS/MS

Ziyuglycoside I and ziyuglycoside II are important active components of Sanguisorba officinalis L., which have excellent pharmacological effects, such as antioxidant and anticancer effects. However, the bioavailability of ziyuglycoside I and ziyuglycoside II has not been reported. This work aims to establish a UPLC-MS/MS method to study the pharmacokinetics of ziyuglycoside I and ziyuglycoside II in rats under different administration routes (intragastric and intravenous administration) and to calculate the bioavailability. The concentration of ziyuglycoside I and ziyuglycoside II in rat plasma in the range of 2–2000 ng/mL showed a good linear relationship (r > 0.99). The intra-day accuracies of ziyuglycoside I and ziyuglycoside II ranged from 87% to 110%, and the inter-day accuracies ranged from 97% to 109%. The intra-day precision was less than 15% and the inter-day precision was less than 14%. The matrix effects ranged from 88% to 113%. The recoveries were all above 84%. The developed UPLC-MS/MS method for the determination of ziyuglycoside I and ziyuglycoside II in rat plasma was applied to pharmacokinetics. The bioavailability of ziyuglycoside I and ziyuglycoside II was measured at 2.6% and 4.6%, respectively.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.