能将大鼠触觉信息转化为痛觉信息的层状选择性脊髓星形胶质细胞群

IF 3 3区医学 Q2 PHARMACOLOGY & PHARMACY

Journal of pharmacological sciences Pub Date : 2024-02-27 DOI:10.1016/j.jphs.2024.02.014

Daichi Sueto , Akihisa Onishi , Eriko I , Yu Yoshikawa , Makoto Tsuda

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引用次数: 0

摘要

我们之前发现了一种表达毛发和分裂增强子 5（Hes5）的脊髓星形胶质细胞群，它们选择性地存在于小鼠的浅层板层中。然而，这种星形胶质细胞的异质性在不同物种中是否普遍存在尚不清楚。利用含有大鼠 Hes5 启动子（AAV-Hes5P）的腺相关病毒（AAV）载体，我们发现 AAV-Hes5P 捕获的星形胶质细胞选择性地位于大鼠的浅层板层。此外，激活 AAV-Hes5P+ 星形胶质细胞可诱发类似异动症的行为，并增加表层的 c-FOS+ 细胞。因此，层状选择性 Hes5+ 星形胶质细胞在物种间是保守的，并有能力将触觉信息转化为痛觉信息。

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Laminar-selective spinal astrocyte population capable of converting tactile information into nociceptive in rats

We previously identified a spinal astrocyte population that expresses hairy and enhancer of split 5 (Hes5) and is selectively present in superficial laminae in mice. However, it was unclear whether such astrocyte heterogeneity is commonly observed across species. Using adeno-associated viral (AAV) vectors incorporating a rat Hes5 promotor (AAV-Hes5P), we found that AAV-Hes5P-captured astrocytes were selectively located in the superficial laminae in rats. Furthermore, activation of AAV-Hes5P⁺ astrocytes elicited allodynia-like behavior and increased c-FOS⁺ cells in the superficial laminae. Thus, laminar-selective Hes5⁺ astrocytes are conserved beyond species and have the capability to convert tactile information to nociceptive.

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来源期刊

Journal of pharmacological sciences 医学-药学

CiteScore

6.20

自引率

2.90%

发文量

104

审稿时长

31 days

期刊介绍： Journal of Pharmacological Sciences (JPS) is an international open access journal intended for the advancement of pharmacological sciences in the world. The Journal welcomes submissions in all fields of experimental and clinical pharmacology, including neuroscience, and biochemical, cellular, and molecular pharmacology for publication as Reviews, Full Papers or Short Communications. Short Communications are short research article intended to provide novel and exciting pharmacological findings. Manuscripts concerning descriptive case reports, pharmacokinetic and pharmacodynamic studies without pharmacological mechanism and dose-response determinations are not acceptable and will be rejected without peer review. The ethnopharmacological studies are also out of the scope of this journal. Furthermore, JPS does not publish work on the actions of biological extracts unknown chemical composition.