利用体内、体外模型研究发育性阅读障碍的遗传修饰及其表现形式。

IF 1.2 Q4 GENETICS & HEREDITY
Global Medical Genetics Pub Date : 2024-02-27 eCollection Date: 2024-01-01 DOI:10.1055/s-0044-1781456
Zakiyyah M M Zaki, Siti A Ali, Mazira M Ghazali, Faidruz A Jam
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引用次数: 0

摘要

阅读障碍是一种遗传性疾病,目前尚未发现治疗方法,特别是在分子和药物干预层面。本综述概述了目前关于发育性阅读障碍所涉及的环境和遗传因素的研究结果。用于诊断该疾病的最新技术和大分子因素的研究结果,可能有助于更深入地了解如何正确管理和治疗阅读障碍患者。此外,本综述试图将目前阅读障碍研究中使用的所有模型汇总起来,供今后的研究参考,其中包括动物模型和体外模型,以及以往的研究如何在不同年份和地区提供一致的数据。因此,我们建议在现有基因多态性、通路和神经元功能输入的基础上,使用类器官模型进一步开展研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Genetic Modifications of Developmental Dyslexia and Its Representation Using In Vivo, In Vitro Model.

Dyslexia is a genetic and heritable disorder that has yet to discover the treatment of it, especially at the molecular and drug intervention levels. This review provides an overview of the current findings on the environmental and genetic factors involved in developmental dyslexia. The latest techniques used in diagnosing the disease and macromolecular factors findings may contribute to a higher degree of development in detangling the proper management and treatment for dyslexic individuals. Furthermore, this review tried to put together all the models used in the current dyslexia research for references in future studies that include animal models as well as in vitro models and how the previous research has provided consistent data across many years and regions. Thus, we suggest furthering the studies using an organoid model based on the existing gene polymorphism, pathways, and neuronal function input.

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来源期刊
Global Medical Genetics
Global Medical Genetics GENETICS & HEREDITY-
自引率
11.80%
发文量
30
审稿时长
14 weeks
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