碰撞瘤多结节空泡型神经元肿瘤,伴有异柠檬酸脱氢酶突变型弥漫性星形细胞瘤。

IF 1.3 4区 医学 Q4 CLINICAL NEUROLOGY
Neuropathology Pub Date : 2024-10-01 Epub Date: 2024-02-27 DOI:10.1111/neup.12968
Vinodh A Kumar, Alejandro Perez, Angela L Young, Julia Jones, Barbara J O'Brien, Frederick F Lang, Jason T Huse, Gregory N Fuller
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引用次数: 0

摘要

在此,我们报告了一例涉及多结节空泡神经元瘤(MVNT)和弥漫性星形细胞瘤的碰撞肿瘤。这两种肿瘤之间的碰撞瘤以前从未报道过。患者是一名 35 岁女性,因新发听力损失和右耳耳鸣就诊。磁共振成像检查发现,左侧额中回灰质和皮质下白质有一非增强性肿块。此外,还发现左侧额上回皮质下带和皮质下浅层白质有微小的簇状结节。患者接受了左额叶开颅手术并完全切除了肿块。切除标本的组织学检查显示,肿瘤由弥漫性星形细胞瘤(异柠檬酸脱氢酶[IDH]突变,中枢神经系统[CNS]世界卫生组织[WHO]2级)和MVNT碰撞而成,后者显示出特征性的形态学和免疫组化特征。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Collision tumor: Multinodular and vacuolating neuronal tumor with isocitrate dehydrogenase-mutant diffuse astrocytoma.

Herein, we report a case of a collision tumor involving a multinodular and vacuolating neuronal tumor (MVNT) and a diffuse astrocytoma. A collision tumor between these two entities has not previously been reported. The patient is a 35-year-old woman who presented with new-onset hearing loss and ringing in her right ear. Magnetic resonance imaging identified a non-enhancing mass involving the gray matter and subcortical white matter of the left middle frontal gyrus. Additionally, tiny clustered nodules were noted along the underlying subcortical ribbon and superficial subcortical white matter of the left superior frontal gyrus. The patient underwent a left frontal craniotomy and complete resection of the mass. Histologic examination of the resected specimen demonstrated a collision tumor consisting of a diffuse astrocytoma (isocitrate dehydrogenase [IDH] mutant, central nervous system [CNS] World Health Organization [WHO] grade 2) and an MVNT, with the latter demonstrating characteristic morphologic and immunohistochemical features.

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来源期刊
Neuropathology
Neuropathology 医学-病理学
CiteScore
4.10
自引率
4.30%
发文量
105
审稿时长
6-12 weeks
期刊介绍: Neuropathology is an international journal sponsored by the Japanese Society of Neuropathology and publishes peer-reviewed original papers dealing with all aspects of human and experimental neuropathology and related fields of research. The Journal aims to promote the international exchange of results and encourages authors from all countries to submit papers in the following categories: Original Articles, Case Reports, Short Communications, Occasional Reviews, Editorials and Letters to the Editor. All articles are peer-reviewed by at least two researchers expert in the field of the submitted paper.
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