癌症中的长非编码 RNA:多方面的作用和免疫疗法的潜在靶点。

IF 3.5 2区 生物学 Q3 CELL BIOLOGY
Molecular and Cellular Biochemistry Pub Date : 2024-12-01 Epub Date: 2024-02-28 DOI:10.1007/s11010-024-04933-1
Lokesh K Kadian, Deepika Verma, Neelam Lohani, Ritu Yadav, Shalu Ranga, Gulshan Gulshan, Sanghapriya Pal, Kiran Kumari, Shyam S Chauhan
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引用次数: 0

摘要

癌症仍然是全球关注的主要健康问题,其死亡率高主要是由于诊断晚和预后差。长非编码 RNA(lncRNA)正在成为人类癌症基因表达的关键调控因子,通过各种机制发挥作用,包括作为竞争性内源性 RNA(ceRNA)和间接调控 miRNA 的表达。研究发现,LncRNAs 在癌症中具有致癌和抑癌作用,前者可促进癌细胞增殖、迁移、侵袭和不良预后。最新研究表明,lncRNAs 在各种免疫细胞中均有表达,并参与癌细胞的免疫逃逸和肿瘤微环境的调控,从而凸显了其作为癌症免疫疗法靶点的潜力。以癌症或免疫细胞中的lncRNAs为靶点,可以增强抗肿瘤免疫反应,改善癌症免疫治疗效果。然而,要全面了解 lncRNA 在癌症和免疫系统中的功能作用及其作为癌症免疫疗法靶点的潜力,还需要进一步的研究。本综述全面探讨了 lncRNAs 在人类癌症中的多方面作用,重点关注它们作为癌症免疫疗法靶点的潜力。通过探讨lncRNA介导的癌细胞增殖、侵袭和免疫逃避调控的复杂机制,我们深入探讨了这些分子的各种治疗应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Long non-coding RNAs in cancer: multifaceted roles and potential targets for immunotherapy.

Cancer remains a major global health concern with high mortality rates mainly due to late diagnosis and poor prognosis. Long non-coding RNAs (lncRNAs) are emerging as key regulators of gene expression in human cancer, functioning through various mechanisms including as competing endogenous RNAs (ceRNAs) and indirectly regulating miRNA expression. LncRNAs have been found to have both oncogenic and tumor-suppressive roles in cancer, with the former promoting cancer cell proliferation, migration, invasion, and poor prognosis. Recent research has shown that lncRNAs are expressed in various immune cells and are involved in cancer cell immune escape and the modulation of the tumor microenvironment, thus highlighting their potential as targets for cancer immunotherapy. Targeting lncRNAs in cancer or immune cells could enhance the anti-tumor immune response and improve cancer immunotherapy outcomes. However, further research is required to fully understand the functional roles of lncRNAs in cancer and the immune system and their potential as targets for cancer immunotherapy. This review offers a comprehensive examination of the multifaceted roles of lncRNAs in human cancers, with a focus on their potential as targets for cancer immunotherapy. By exploring the intricate mechanisms underlying lncRNA-mediated regulation of cancer cell proliferation, invasion, and immune evasion, we provide insights into the diverse therapeutic applications of these molecules.

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来源期刊
Molecular and Cellular Biochemistry
Molecular and Cellular Biochemistry 生物-细胞生物学
CiteScore
8.30
自引率
2.30%
发文量
293
审稿时长
1.7 months
期刊介绍: Molecular and Cellular Biochemistry: An International Journal for Chemical Biology in Health and Disease publishes original research papers and short communications in all areas of the biochemical sciences, emphasizing novel findings relevant to the biochemical basis of cellular function and disease processes, as well as the mechanics of action of hormones and chemical agents. Coverage includes membrane transport, receptor mechanism, immune response, secretory processes, and cytoskeletal function, as well as biochemical structure-function relationships in the cell. In addition to the reports of original research, the journal publishes state of the art reviews. Specific subjects covered by Molecular and Cellular Biochemistry include cellular metabolism, cellular pathophysiology, enzymology, ion transport, lipid biochemistry, membrane biochemistry, molecular biology, nuclear structure and function, and protein chemistry.
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