COVID-19 大流行期间炎症性肠病的流行病学:两个全国性队列的比较。

Ohad Atia, Nicklas Bryder, Adi Mendelovici, Natan Ledderman, Amir Ben-Tov, Mehdi Osooli, Anders Forss, Yiska Loewenberg Weisband, Eran Matz, Iris Dotan, Dan Turner, Ola Olén
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引用次数: 0

摘要

背景:我们的目的是在两个封锁政策不同的国家探索与COVID-19大流行相关的炎症性肠病(IBD)流行病学:我们利用以色列和瑞典的全国性 IBD 队列,探讨大流行期间 IBD 的发病率与之前三年(2017-2019 年)的比较。我们通过Joinpoint回归分析检验了拐点存在的时间趋势,并报告了月平均百分比变化(AMPC):共纳入155837名IBD患者(以色列58640人;瑞典97197人)。直到2019年,两国的IBD年发病率一直保持稳定,此后,以色列的发病率有所下降(AAPC为-16.6% [95%CI -19.9%至-10.0%]),瑞典的发病率保持稳定(AAPC为-3.5% [95%CI -11.6%至3.7%])。在探讨大流行期间的月发病率时,以色列的发病率在 2020 年 11 月之前保持稳定(AMPC 2.3% [95%CI -13.4% to 29.9%]),然后在 2021 年 2 月之前急剧下降(AMPC -6.4% [95%CI-20.8% to 17.0%]),在 2021 年 2 月之前为-20.1%[95%CI-38.9%至-4.7%]),而瑞典的封锁政策较宽松,其发病率在 2020 年 7 月前略有下降(AMPC-3.3%[95%CI-21.6%至 20.3%]),但之后有所上升(AMPC 13.6%[95%CI-12.6%至 27.0%])。瑞典发病率的变化主要发生在老年患者身上,而老年患者是大流行期间发病率明显下降的唯一人群:结论:大流行期间,IBD发病率的下降与封锁有关,政策更为严格的以色列的情况更为严重。未来需要开展研究,以确定大流行对 IBD 的长期影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Epidemiology of Inflammatory Bowel Diseases During the COVID-19 Pandemic: Comparison of Two Nationwide Cohorts.

Background: We aimed to explore the epidemiology of inflammatory bowel diseases [IBD] in association with the COVID-19 pandemic in two countries with different lockdown policies.

Methods: We utilized nationwide IBD cohorts in Israel and Sweden to explore the incidence of IBD during the pandemic compared to 3 years prior [2017-2019]. We examined temporal trends through the presence of inflection points by Joinpoint regression analysis and reported average monthly percentage changes [AMPC].

Results: A total of 155 837 patients with IBD were included [Israel, 58 640; Sweden, 97 197]. The annual incidence of IBD was stable until 2019 in both countries but then decreased in Israel (AAPC -16.6% [95% confidence interval, CI, -19.9% to -10.0%]) and remained stable in Sweden (AAPC -3.5% [95% CI -11.6% to 3.7%]). When exploring the monthly incidence during the pandemic, in Israel the rate remained stable until November 2020 (AMPC 2.3% [95% CI -13.4% to 29.9%]) and then decreased sharply (AMPC -6.4% [95% CI -20.8% to 17.0%] until February 2021 and to -20.1% [95% CI -38.9% to -4.7%] from February 2021), while in Sweden, which had a less stringent lockdown policy, it decreased slightly until July 2020 (AMPC -3.3% [95% CI -21.6% to 20.3%]), but increased thereafter (AMPC 13.6% [95% CI -12.6% to 27.0%]). The change of incidence rate in Sweden occurred mainly in elderly-onset patients, the only population with significant restrictions during the pandemic.

Conclusion: The incidence of IBD decreased during the pandemic in association with lockdowns, more so in Israel, which had more stringent policies. Future studies are needed to determine the long-term effect of the pandemic on IBD.

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