利用 18F-FDG 全身 PET/CT 的短采集时间识别小儿癫痫灶的疗效。

IF 3.1 3区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Min Li, Xiao Cui, Huixin Yue, Chao Ma, Kun Li, Leiying Chai, Min Ge, Hui Li, Yee Ling Ng, Yun Zhou, Jianguo Shi, Yanhua Duan, Zhaoping Cheng
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引用次数: 0

摘要

背景:18F-FDG 正电子发射断层扫描(PET)在小儿癫痫患者治疗前的评估中起着至关重要的作用。短期扫描具有重要意义,尤其是对于表现出不自主运动的小儿癫痫患者。本研究旨在评估使用全身 PET/CT 扫描小儿癫痫患者时,短采集时间对图像质量和病灶可探测性的影响。回顾性研究共纳入了25名使用uEXPLORER扫描仪进行全身PET/CT检查的儿科患者,18F-FDG给药剂量为3.7 MBq/kg,采集时间为600秒。通过在列表模式下截断 PET 数据以降低计数密度,模拟了短采集时间(60 秒、150 秒和 300 秒)。主观图像质量按 5 分制评分。对疑似致痫区(EZs)、EZs 对侧相应位置和健康小脑皮层进行感兴趣区分析,比较短时间图像的半定量摄取指数,然后与 600 秒图像进行比较。结果:我们的研究表明,150 秒的短采集时间足以保持主观图像质量和病变的显著性。统计分析显示,300 秒和 150 秒的 PET 图像主观质量无明显差异(P > 0.05)。G60s 的图像质量和病灶清晰度的总体印象分数均大于 3(总体质量,3.21 ± 0.46;病灶清晰度,4.08 ± 0.74)。随着采集时间的缩短,各组小脑皮质的 SUVmax 和 SD 变化逐渐增大(P 15%)。在25名患者的26个EZ中,当时间缩短至60秒时,病变检出率仍为100%:本研究提出,结核病 PET/CT 采集时间可缩短至 60 秒,且病变检出率可接受。此外,该研究还提出,150 秒的采集时间足以达到癫痫患儿的诊断性能和图像质量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The efficacy of short acquisition time using 18F-FDG total-body PET/CT for the identification of pediatric epileptic foci.

Background: 18F-FDG positron emission tomography (PET) plays a crucial part in the evaluation for pediatric epileptic patients prior to therapy. Short-term scanning holds significant importance, especially for pediatrics epileptic individuals who exhibited involuntary movements. The aim was to evaluate the effects of short acquisition time on image quality and lesion detectability in pediatric epileptic patients using total-body (TB) PET/CT. A total of 25 pediatric patients who underwent TB PET/CT using uEXPLORER scanner with an 18F-FDG administered dose of 3.7 MBq/kg and an acquisition time of 600 s were retrospectively enrolled. Short acquisition times (60 s, 150 and 300 s) were simulated by truncating PET data in list mode to reduce count density. Subjective image quality was scored on a 5-point scale. Regions of interest analysis of suspected epileptogenic zones (EZs), corresponding locations contralateral to EZs, and healthy cerebellar cortex were used to compare the semi-quantitative uptake indices of short-time images and then were compared with 600 s images. The comparison of EZs detectability based on time-dependent PET images was performed.

Results: Our study demonstrated that a short acquisition time of 150 s is sufficient to maintain subjective image quality and lesion significance. Statistical analysis revealed no significant difference in subjective PET image quality between imaging at 300 s and 150 s (P > 0.05). The overall impression scores of image quality and lesion conspicuity in G60s were both greater than 3 (overall quality, 3.21 ± 0.46; lesion conspicuity, 4.08 ± 0.74). As acquisition time decreased, the changes of SUVmax and SD in the cerebellar cortex gradually increased (P < 0.01). There was no significant difference in asymmetry index (AI) difference between the groups and the AIs of EZs were > 15% in all groups. In 26 EZs of 25 patients, the lesion detection rate was still 100% when the time was reduced to 60 s.

Conclusions: This study proposed that TB PET/CT acquisition time could be reduced to 60 s with acceptable lesion detectability. Furthermore, it was suggested that a 150 s acquisition time would be sufficient to achieve diagnostic performance and image quality for children with epilepsy.

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来源期刊
EJNMMI Research
EJNMMI Research RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING&nb-
CiteScore
5.90
自引率
3.10%
发文量
72
审稿时长
13 weeks
期刊介绍: EJNMMI Research publishes new basic, translational and clinical research in the field of nuclear medicine and molecular imaging. Regular features include original research articles, rapid communication of preliminary data on innovative research, interesting case reports, editorials, and letters to the editor. Educational articles on basic sciences, fundamental aspects and controversy related to pre-clinical and clinical research or ethical aspects of research are also welcome. Timely reviews provide updates on current applications, issues in imaging research and translational aspects of nuclear medicine and molecular imaging technologies. The main emphasis is placed on the development of targeted imaging with radiopharmaceuticals within the broader context of molecular probes to enhance understanding and characterisation of the complex biological processes underlying disease and to develop, test and guide new treatment modalities, including radionuclide therapy.
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