制备和表征乙烯基二氧化硅支撑表面分子印迹聚合物,并将其与液相色谱-质谱联用,用于提取化妆品中的前列腺素类似物

Aqeel Shahzad, Farzana Batool, Kamran Bashir, Jiameng Xu, Qiang Fu
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引用次数: 0

摘要

前列腺素类似物(PGAs)常用于治疗眼压过高和青光眼患者。如今,在化妆品中使用前列腺素类似物可增强睫毛,特别是在睫毛稀少的情况下。本研究以比马前列素为模板分子,结合液相色谱-质谱(LC-MS)系统,合成了用于选择性提取 PGAs(比马前列素、拉坦前列素和曲伏前列素)的表面分子印迹聚合物。扫描电子显微镜和傅立叶变换红外光谱技术用于研究其形态和物理特性。吸附选择性研究表明 PGAs 具有高选择性。比马前列素、拉坦前列素和曲伏前列素的吸附容量分别为 93.8、92.3 和 91.5 μg/g。测试了比马前列素、拉坦前列素和曲伏前列素三个浓度水平(10-30 纳克/毫升)样品的回收率和精密度(98.5%-102.5%,1.2%-4.5%,n = 3)。比马前列素、拉坦前列素和曲伏前列素的方法重复性相对标准偏差分别为 1.8 至 5.6%、1.5 至 4.8%、1.6 至 5.2%。比马前列素、拉坦前列素和曲伏前列素的检出限分别为 0.20、0.25 和 0.45 纳克/毫升。表面分子印迹聚合物与液相色谱-质谱联用的方法成功地应用于化妆品中PGAs的选择性提取。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Preparation and characterization of vinyl silica‐supported surface molecularly imprinted polymers coupled with liquid chromatography‐mass spectrometry for extraction of prostaglandin analogs from cosmetic products
Prostaglandin analogs (PGAs) are commonly used to treat ocular hypertension and glaucoma patients. Nowadays, the use of PGAs enhances eyelashes in cosmetics, particularly in the condition of hypotrichosis. A method was developed in which surface molecularly imprinted polymers were synthesized for selective extraction of PGAs (bimatoprost, latanoprost, and travoprost) by using bimatoprost as template molecules which were coupled with liquid chromatography‐mass spectrometry (LC‐MS) system. Scanning electron microscopy and Fourier‐transform infrared spectroscopy techniques were used to study the morphological and physical characterization. The adsorption selectivity studies showed the high selectivity of PGAs. The adsorption capacities of bimatoprost, latanoprost, and travoprost were 93.8, 92.3, and 91.5 μg/g, respectively. The recoveries and precision of samples at three concentration levels (10–30 ng/mL) of bimatoprost, latanoprost, and travoprost were tested (98.5%–102.5%, 1.2%–4.5%, n = 3). The % relative standard deviation for repeatability of the method for bimatoprost, latanoprost, and travoprost ranged from 1.8 to 5.6, 1.5 to 4.8, and 1.6 to 5.2, respectively. While the limit of detection for bimatoprost, latanoprost, and travoprost was 0.20, 0.25, and 0.45 ng/mL, respectively. The method of surface molecularly imprinted polymer coupled with LC‐MS was successfully applied to cosmetic products for selective extraction of PGAs.
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