印度东部一家三级医疗中心受 COVID-19 影响孕妇的围产期结果

Sujata Pendyala, Shiwangi Kumari, Tanushree Sandipta Rath, Chandrabhanu Dalal, Dattatreya Kar, Sujata Priyadarshini Mishra
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摘要

妊娠是一种免疫功能低下的状态,感染 COVID-19 的孕妇围产期发生不良后果的风险较高。为了研究受 COVID-19 影响的孕妇的围产期结果,我们对 320 名 COVID-19 阳性的产前患者进行了为期 18 个月的前瞻性观察研究。研究记录了 COVID-19 孕妇的临床表现、人口统计学特征和妊娠结局。对重要的实验室参数以及 COVID-19 炎症指标(如血清铁蛋白、D-二聚体、CRP 等)进行了评估。新生儿结局评估包括 APGAR 评分、胎儿死亡、出生体重、新生儿重症监护室入院情况。通过检测新生儿咽拭子样本中的 SARS-CoV-2 阳性来筛查新生儿感染。52.19%的患者无 COVID-19 症状,34.69%的患者有发烧症状。最常见的风险因素是甲状腺功能减退。22%的患者出现贫血,30%的患者凝血指标升高,90%以上的患者COVID-19炎症指标升高。产妇和新生儿入住重症监护室的比例分别为 4.69% 和 30.34%。新生儿感染率为 3.1%。COVID-19 主要见于初产妇,但不影响婴儿的出生体重。30%的患者凝血功能和肾功能指标出现异常,但未出现危及生命的并发症。COVID-19 特异性炎症标记物在 90% 以上的病例中显示失常,尽管其中大多数没有症状。新生儿 COVID-19 阳性率为 3.1%。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Perinatal outcomes of COVID-19 affected pregnant women in a tertiary care center of eastern India
Pregnancy is an immune-compromised state and pregnancy affected with COVID-19 infection is at a higher risk of adverse perinatal results. Data on feto-maternal outcomes in pregnancies infected with COVID-19 is sparse, which makes it difficult to draw conclusions on vertical transmission.To study the perinatal outcomes of covid-19 affected pregnant women.A prospective observational study was conducted over eighteen months, on 320 COVID-19 positive antenatal patients. Clinical manifestations of pregnancies with COVID-19, demographic profile, pregnancy outcomes were recorded. Important laboratory parameters were assessed along with COVID-19 inflammatory markers like serum ferritin,D-Dimer, CRP etc. Neonatal outcomes assessed included APGAR score, fetal deaths, birth weight, NICU admissions. Neonatal infections were screened by testing for SARS-CoV-2 positivity in neonatal throat swab samples.61.5% of patients complained of pain abdomen, followed by bleeding PV in 1.9%. 52.19% of the patients were asymptomatic for COVID-19 symptoms, followed by fever in 34.69%. Most common risk factor associated was hypothyroidism. Anemia was found in 22%, coagulation parameters were elevated in 30% and COVID-19 inflammatory markers were raised in more than 90% cases. Maternal and neonatal ICU admission rates were 4.69% and 30.34% respectively. Neonatal infection rate was 3.1%.COVID-19 was mainly seen in primigravida, without affecting the birth weight of babies. Coagulation profile and renal parameters were deranged in 30 percent of the patients, without any life any threatening complications. COVID-19 specific inflammatory markers showed derangement in more than 90% cases, although majority of them were asymptomatic. The rate of COVID-19 positivity among newborns was 3.1%.
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