北印度三级医疗中心癌症患者 1 年内不同性质神经病理性疼痛的发生率--一项观察性研究

IF 1.1 Q4 HEALTH CARE SCIENCES & SERVICES
Shipra Singh, Sanjay Dhiraaj, Chetna Shamshery, Shalini Singh, Anjali Singh, Rajput Abhishek Kumar, Prabhaker Mishra
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引用次数: 0

摘要

疼痛可分为痛觉性疼痛、神经病理性疼痛或神经痉挛性疼痛。神经病理性疼痛根据特定的病因和病理生理学表现为不同的表型(特征)。本研究旨在了解癌症患者中不同表型神经病理性疼痛的发生率,并根据潜在的神经生理学和感觉特征与各器官系统的关联形成特定的表型群--一项前瞻性观察研究。研究获得了机构伦理委员会的批准(IEC 代码:2020-49-MD-EXP-15)https://ctri.nic.in/Clinicaltrials/showallp.php?mid1=44886&EncHid=88651.15716&userName=CTRI/2020/09/027964。在获得书面知情同意后,在疼痛与姑息门诊部或放疗部登记并主诉疼痛且未服用任何抗神经病理性疼痛药物的 18-80 岁年龄组患者被纳入研究。在 210 名主诉疼痛的癌症患者中,73 人(34.76%)的神经病理性症状和体征(LANSS)评分高于 12 分。72.60%、56.16%和43.84%的患者发现了最主要的表型:异痛>刺痛>刺痛=灼痛。根据临床上显著的表型分离,将表型分为节点 1 和节点 2。节点 1 主要是胃肠道(GIT)和泌尿生殖道(GUT)癌症患者的自发性神经病理性疼痛。对患者的仔细评估显示,神经病理性疼痛的发生率为 34.76%;异痛和刺痛是最突出的表型。从广义上讲,感觉特征可分为自发感觉和刺激诱发感觉,其中消化道和上消化道癌症表现为节点1症状。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Incidence of Different Characters of Neuropathic Pain in Cancer Patients Coming to Tertiary Care Centre in North India Over A Period of 1 Year – An Observational Study
Pain is classified as nociceptive, neuropathic, or nociplastic. Neuropathic pain presents as variable phenotypes (characters) based on specific aetiology and pathophysiology. This study aimed to find out among cancer patients the incidence of different phenotypes of neuropathic pain and form specific phenotypic clusters based on the underlying neurophysiology and association of sensory profile with various organ systems – A prospective observational study. The Institutional Ethical Committee clearance (IEC code: 2020-49-MD-EXP-15) https://ctri.nic.in/Clinicaltrials/showallp.php?mid1=44886&EncHid=88651.15716&userName=CTRI/2020/09/027964 approval was obtained. After written and informed consent, patients of age group 18–80 years, registering in the pain and palliative outpatient department or radiotherapy department with complaints of pain and not taking any anti-neuropathic pain medications, were enrolled. They were assessed using Leeds assessment of neuropathic symptoms and signs (LANSS) pain score, and a score of >12 was eligible for assessment of neuropathic pain phenotypes. Out of 210 cancer patients complaining of pain, a neuropathic component with LANSS >12 was found in 73 (34.76%). The most predominant phenotypes, allodynia> tingling> pricking = burning, were found in 72.60%, 56.16%, and 43.84% of patients, respectively. Phenotypes were clustered into Nodes 1 and 2 based on clinically significant separation of phenotypes. Node 1 had neuropathic pain of spontaneous origin found predominantly in gastrointestinal tract (GIT) and genitourinary tract (GUT) cancers. Node 2 had stimulus-evoked negative and positive characters which occurred in head and neck, thoracic, and spinal metastatic cancers. Careful patient assessment reveals the incidence of neuropathic pain in 34.76%; allodynia and tingling astable the most prominent phenotypes. Broadly, sensory characters were clustered into spontaneous and stimulus-evoked sensations with GIT and GUT cancers presenting with Node 1 symptoms.
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来源期刊
Indian Journal of Palliative Care
Indian Journal of Palliative Care HEALTH CARE SCIENCES & SERVICES-
CiteScore
2.30
自引率
0.00%
发文量
57
期刊介绍: Welcome to the website of the Indian Journal of Palliative Care. You have free full text access to recent issues of the journal. The links connect you to •guidelines and systematic reviews in palliative care and oncology •a directory of palliative care programmes in India and IAPC membership •Palliative Care Formulary, book reviews and other educational material •guidance on statistical tests and medical writing.
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