预测 T1 - 4、N0、M0 肾细胞癌患者肿瘤生物学行为的术前血小板比值与中性粒细胞和淋巴细胞比值:回顾性分析

IF 0.4 Q4 ONCOLOGY
Surag Kr, A. Choudhary, Anshuman Singh, Swathi Pm, Kasi Vishwanath, Mithun Rao
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引用次数: 0

摘要

背景:肾细胞癌(RCC)是一种全球流行的侵袭性癌症。研究目的我们研究了术前血清血小板克里特(PCT)水平能否预测T1-4、N0和M0 RCC手术患者的肿瘤分期和病理分级。此外,我们还将其与中性粒细胞与淋巴细胞比值(NLR)进行了比较。方法:我们对2016年1月至2022年12月期间在我院接受肾切除术(根治术或部分切除术)的196名T1-4、N0和M0 RCC患者进行了回顾性评估。根据组织病理学结果,确定了肿瘤分期(T)和WHO-ISUP分级(G)。根据T分期(T1 - T2和T3 - T4)和病理分级(G1 - 2和G3 - 4)将患者分为两类。研究比较了 NLR、PCT 及其组合值,以确定它们在根据肿瘤的病理分期和分级预测侵袭性方面的作用。研究结果结果发现,NLR 和 PCT 的平均临界值在肿瘤分期高时分别为 2.108 和 0.273,在肿瘤分级高时分别为 2.237 和 0.252。统计分析显示,NLR(P = 0.031)和 PCT(P = 0.006)对肿瘤高分期有显著预测作用,而只有 PCT(P = 0.022)对 WHO-ISUP 高分级有显著预测作用。结合使用 NLR 和 PCT 有助于提高检测高级别肿瘤的灵敏度。结论NLR 和 PCT 可作为肿瘤分期的预测指标。但是,只有 PCT 可以预测 RCC 患者的肿瘤分级。此外,结合 PCT 和 NLR 评分可提高各参数的预测能力,尤其是在识别高级别肿瘤方面。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pre-operative Plateletcrit vs. Neutrophil to Lymphocyte Ratio in Predicting Biological Tumor Behavior in Patients with T1 - 4, N0, M0 Renal Cell Carcinoma: A Retrospective Analysis
Background: Renal cell carcinoma (RCC) is an aggressive cancer prevalent worldwide. Objectives: We investigated whether preoperative serum levels of plateletcrit (PCT) can predict tumor stages and pathological grades in patients, who were operated on for T1 - 4, N0, and M0 RCC. Additionally, we compared it with neutrophil to lymphocyte ratio (NLR). Methods: We conducted a retrospective evaluation of 196 patients, who had undergone nephrectomy (radical or partial) for T1 v- 4, N0, and M0 RCC at our hospital from January 2016 to December 2022. Based on their histopathology results, tumor stages (T) and WHO-ISUP grades (G) were identified. The patients were separated into two categories depending on their T-stage (T1 - T2 and T3 - T4) and pathological grade (G1 - 2 and G3 - 4). The study compared the NLR, PCT, and their combined values to determine their role in predicting aggressiveness based on pathological stage and grade of tumors. Results: The mean cut-off values for NLR and PCT were found to be 2.108 and 0.273, for the high tumor stage and 2.237 and 0.252 for high-grade tumors, respectively. The statistical analysis showed that NLR (P = 0.031) and PCT (P = 0.006) were significant predictors of high tumor stage, while only PCT (P = 0.022) was a significant predictor of high WHO-ISUP grade. The combination of both NLR and PCT helps improve the sensitivity for detecting high-grade tumors. Conclusions: NLR and PCT can be predictive markers of the tumor stage. However, only PCT can predict the tumor grade in patients with RCC. In addition, combining the PCT and NLR scores improved the predictive ability of each parameter, especially for identifying high-grade tumors.
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来源期刊
CiteScore
1.10
自引率
0.00%
发文量
67
期刊介绍: International Journal of Cancer Management (IJCM) publishes peer-reviewed original studies and reviews on cancer etiology, epidemiology and risk factors, novel approach to cancer management including prevention, diagnosis, surgery, radiotherapy, medical oncology, and issues regarding cancer survivorship and palliative care. The scope spans the spectrum of cancer research from the laboratory to the clinic, with special emphasis on translational cancer research that bridge the laboratory and clinic. We also consider original case reports that expand clinical cancer knowledge and convey important best practice messages.
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