Angioid Streaks Secondary to Pseudoxanthoma Elasticum: About Two Cases

This bilateral, often asymmetrical and usually progressive disease, was first described by Knapp in 1892. Angioid streaks are often observed in the context of general pathologies, in particular pseudoxanthoma elasticum, found in 53 to 65% of cases [1,2], an autosomal recessive disease caused by the mutation of the ABCC6 gene [3].Other diseases with which angioid streaks may be associated include, Paget's disease (of unknown origin), sickle cell disease (autosomal recessive inheritance), senile elastosis of the skin, certain vascular disorders associated with arterial hypertension, and more rarely Ehlers-Danlos syndrome (autosomal dominant inheritance). Here, we report two cases of angioid streaks secondary to pseudoxanthoma elasticum.