心肌梗死与甘油三酯-葡萄糖指数之间的关系：基于 NHANES 数据库的研究

IF 3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Global Heart Pub Date : 2024-02-23 DOI:10.5334/gh.1303

Dandan Zheng, Ligong Cao

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引用次数: 0

摘要

目的研究心肌梗死（MI）患者与非心肌梗死患者甘油三酯-葡萄糖（TyG）指数水平的差异，以及 TyG 指数与心肌梗死风险之间的关联。研究方法本研究纳入了 2013 年至 2018 年美国成人国家健康与营养调查（NHANES）的数据。以MI为结果变量，TyG指数为暴露变量，采用逻辑回归模型分析MI与TyG指数之间的关系。结果：研究共纳入 6695 名参与者。与非心肌梗死组相比，心肌梗死患者的 TyG 指数明显更高（8.89 对 8.63，P = 0.003）。在美国成年人中，TyG指数越高，罹患心肌梗死的风险越高（OR：1.69，95% CI：1.26-2.26，P <0.001）。种族、吸烟状况和慢性阻塞性肺病（COPD）病史对TyG指数与心肌梗死风险之间的关系有显著影响（交互作用的P为0.05）。亚组分析表明，在多个模型中，非西班牙裔黑人、非吸烟者和无慢性阻塞性肺病者的TyG指数与心肌梗死风险呈显著正相关（OR >1.0，P <0.05）。结论TyG指数较高的美国成年人更易患心肌梗死，TyG指数可用于识别美国人群中的心肌梗死高危人群。

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Association Between Myocardial Infarction and Triglyceride-Glucose Index: A Study Based on NHANES Database

Objective: To investigate differences in levels of the triglyceride-glucose (TyG) index between individuals with myocardial infarction (MI) and those without MI, as well as the association between TyG index and risk of MI. Methods: Data from the National Health and Nutrition Examination Survey (NHANES) for US adults from 2013 to 2018 were included in this study. Using MI as an outcome variable and TyG index as an exposure variable, logistic regression models were employed to analyze relationship between MI and TyG index. Results: The study included 6,695 participants. Compared to the non-MI group, patients with MI had significantly higher TyG index (8.89 vs. 8.63, P = 0.003). Higher TyG index was significantly associated with an increased risk of MI in US adults (OR: 1.69, 95% CI: 1.26–2.26, P < 0.001). Race, smoking status, and history of chronic obstructive pulmonary disease (COPD) had significant impacts on the association between TyG index and risk of MI (P for interaction < 0.05). Subgroup analysis demonstrated a significant positive correlation between TyG index and MI risk in non-Hispanic Black individuals, non-smokers, and individuals without COPD across multiple models (OR > 1.0, P < 0.05). Conclusion: US adults with higher TyG index were more susceptible to MI, and TyG index may be used to identify individuals at high risk of MI in the US population.

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来源期刊

Global Heart Medicine-Cardiology and Cardiovascular Medicine

CiteScore

5.70

自引率

5.40%

发文量

审稿时长

5 weeks

期刊介绍： Global Heart offers a forum for dialogue and education on research, developments, trends, solutions and public health programs related to the prevention and control of cardiovascular diseases (CVDs) worldwide, with a special focus on low- and middle-income countries (LMICs). Manuscripts should address not only the extent or epidemiology of the problem, but also describe interventions to effectively control and prevent CVDs and the underlying factors. The emphasis should be on approaches applicable in settings with limited resources. Economic evaluations of successful interventions are particularly welcome. We will also consider negative findings if important. While reports of hospital or clinic-based treatments are not excluded, particularly if they have broad implications for cost-effective disease control or prevention, we give priority to papers addressing community-based activities. We encourage submissions on cardiovascular surveillance and health policies, professional education, ethical issues and technological innovations related to prevention. Global Heart is particularly interested in publishing data from updated national or regional demographic health surveys, World Health Organization or Global Burden of Disease data, large clinical disease databases or registries. Systematic reviews or meta-analyses on globally relevant topics are welcome. We will also consider clinical research that has special relevance to LMICs, e.g. using validated instruments to assess health-related quality-of-life in patients from LMICs, innovative diagnostic-therapeutic applications, real-world effectiveness clinical trials, research methods (innovative methodologic papers, with emphasis on low-cost research methods or novel application of methods in low resource settings), and papers pertaining to cardiovascular health promotion and policy (quantitative evaluation of health programs.