{"title":"三维断层扫描评估乳腺实质密度及其与恶性病变和绝经状态的关系。","authors":"Tancia Pires , Avantsa Rohini","doi":"10.1016/j.jmir.2024.01.011","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Breast cancer that has a high mortality rate is now known to decrease due to early detection with the advent of digital breast tomosynthesis (DBT or 3D tomosynthesis) screening, especially in those with dense breasts. The risk of breast cancer related to 'changes' in breast density over time remains controversial as breast density and age have an inverse relationship. Breast density as an independent risk factor for breast cancer is known, but its association with menopausal status, if any, has not been studied thoroughly.</p></div><div><h3>Method</h3><p>All patients referred for 3D mammography with breast lesions from June 2022 to January 2023 were considered. Patients were categorized as pre-, peri, and post-menopausal, and each category was further sub-classified based on the breast density as either dense or non-dense and the lesion type, whether benign or malignant. The Statistical analysis was performed using a chi-square test to evaluate whether any association exists between malignancy and menopausal status.</p></div><div><h3>Result</h3><p>A total of 60 patients, with 20 in each category of menopausal stage, were imaged and evaluated. 35% of women had non-dense breasts, while 65% had dense breast parenchyma. Breast density and lesion type were associated significantly (<em>p</em>-value = 0.05) where, out of the 23 benign lesions, 48% occurred in dense women, and 52% in non-dense women respectively. In our study, both benign (<em>N</em> = 7) and malignant (<em>N</em> = 13) lesions occurred in equal numbers in the pre-and peri‑ menopausal women, whereas the number of benign and malignant lesions in the post-menopausal women were 9 (45%) and 11 (55%), respectively. Even though no statistically significant association was found between menopausal status and malignancy in our study, out of the 37 malignant lesions, a majority (76%) of lesions occurred in those having dense breasts (<em>N</em> = 28).</p></div><div><h3>Conclusion</h3><p>Earlier, the notion was that older women had a higher risk of breast cancer compared to younger, but this study has shown that malignancy and menopausal status have a <em>p</em>-value of 0.754, which is not statistically significant. However, both malignant and benign lesions were found more in women having high breast density, in keeping with previous literature. Hence, precaution and care should be taken during pre-, peri, and post-menopausal phases, especially in those patients with high breast density. Apart from breast density, many other risk factors for breast cancer exist, therefore breast density alone is not sufficient to govern the need for screening in women.</p></div>","PeriodicalId":46420,"journal":{"name":"Journal of Medical Imaging and Radiation Sciences","volume":null,"pages":null},"PeriodicalIF":1.3000,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"3D tomosynthesis evaluation of breast parenchymal density and its association with malignant lesions and menopausal status\",\"authors\":\"Tancia Pires , Avantsa Rohini\",\"doi\":\"10.1016/j.jmir.2024.01.011\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>Breast cancer that has a high mortality rate is now known to decrease due to early detection with the advent of digital breast tomosynthesis (DBT or 3D tomosynthesis) screening, especially in those with dense breasts. The risk of breast cancer related to 'changes' in breast density over time remains controversial as breast density and age have an inverse relationship. Breast density as an independent risk factor for breast cancer is known, but its association with menopausal status, if any, has not been studied thoroughly.</p></div><div><h3>Method</h3><p>All patients referred for 3D mammography with breast lesions from June 2022 to January 2023 were considered. Patients were categorized as pre-, peri, and post-menopausal, and each category was further sub-classified based on the breast density as either dense or non-dense and the lesion type, whether benign or malignant. The Statistical analysis was performed using a chi-square test to evaluate whether any association exists between malignancy and menopausal status.</p></div><div><h3>Result</h3><p>A total of 60 patients, with 20 in each category of menopausal stage, were imaged and evaluated. 35% of women had non-dense breasts, while 65% had dense breast parenchyma. Breast density and lesion type were associated significantly (<em>p</em>-value = 0.05) where, out of the 23 benign lesions, 48% occurred in dense women, and 52% in non-dense women respectively. In our study, both benign (<em>N</em> = 7) and malignant (<em>N</em> = 13) lesions occurred in equal numbers in the pre-and peri‑ menopausal women, whereas the number of benign and malignant lesions in the post-menopausal women were 9 (45%) and 11 (55%), respectively. Even though no statistically significant association was found between menopausal status and malignancy in our study, out of the 37 malignant lesions, a majority (76%) of lesions occurred in those having dense breasts (<em>N</em> = 28).</p></div><div><h3>Conclusion</h3><p>Earlier, the notion was that older women had a higher risk of breast cancer compared to younger, but this study has shown that malignancy and menopausal status have a <em>p</em>-value of 0.754, which is not statistically significant. However, both malignant and benign lesions were found more in women having high breast density, in keeping with previous literature. Hence, precaution and care should be taken during pre-, peri, and post-menopausal phases, especially in those patients with high breast density. Apart from breast density, many other risk factors for breast cancer exist, therefore breast density alone is not sufficient to govern the need for screening in women.</p></div>\",\"PeriodicalId\":46420,\"journal\":{\"name\":\"Journal of Medical Imaging and Radiation Sciences\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2024-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Medical Imaging and Radiation Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1939865424000122\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Medical Imaging and Radiation Sciences","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1939865424000122","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
3D tomosynthesis evaluation of breast parenchymal density and its association with malignant lesions and menopausal status
Background
Breast cancer that has a high mortality rate is now known to decrease due to early detection with the advent of digital breast tomosynthesis (DBT or 3D tomosynthesis) screening, especially in those with dense breasts. The risk of breast cancer related to 'changes' in breast density over time remains controversial as breast density and age have an inverse relationship. Breast density as an independent risk factor for breast cancer is known, but its association with menopausal status, if any, has not been studied thoroughly.
Method
All patients referred for 3D mammography with breast lesions from June 2022 to January 2023 were considered. Patients were categorized as pre-, peri, and post-menopausal, and each category was further sub-classified based on the breast density as either dense or non-dense and the lesion type, whether benign or malignant. The Statistical analysis was performed using a chi-square test to evaluate whether any association exists between malignancy and menopausal status.
Result
A total of 60 patients, with 20 in each category of menopausal stage, were imaged and evaluated. 35% of women had non-dense breasts, while 65% had dense breast parenchyma. Breast density and lesion type were associated significantly (p-value = 0.05) where, out of the 23 benign lesions, 48% occurred in dense women, and 52% in non-dense women respectively. In our study, both benign (N = 7) and malignant (N = 13) lesions occurred in equal numbers in the pre-and peri‑ menopausal women, whereas the number of benign and malignant lesions in the post-menopausal women were 9 (45%) and 11 (55%), respectively. Even though no statistically significant association was found between menopausal status and malignancy in our study, out of the 37 malignant lesions, a majority (76%) of lesions occurred in those having dense breasts (N = 28).
Conclusion
Earlier, the notion was that older women had a higher risk of breast cancer compared to younger, but this study has shown that malignancy and menopausal status have a p-value of 0.754, which is not statistically significant. However, both malignant and benign lesions were found more in women having high breast density, in keeping with previous literature. Hence, precaution and care should be taken during pre-, peri, and post-menopausal phases, especially in those patients with high breast density. Apart from breast density, many other risk factors for breast cancer exist, therefore breast density alone is not sufficient to govern the need for screening in women.
期刊介绍:
Journal of Medical Imaging and Radiation Sciences is the official peer-reviewed journal of the Canadian Association of Medical Radiation Technologists. This journal is published four times a year and is circulated to approximately 11,000 medical radiation technologists, libraries and radiology departments throughout Canada, the United States and overseas. The Journal publishes articles on recent research, new technology and techniques, professional practices, technologists viewpoints as well as relevant book reviews.