将童年创伤与精神分裂症的精神病理学联系起来:催产素的作用。

IF 3 Q2 PSYCHIATRY
Yuan-Jung Chen, Mong-Liang Lu, Yi-Hang Chiu, Chenyi Chen, Vitor Hugo Jesus Santos, Kah Kheng Goh
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引用次数: 0

摘要

童年创伤与精神分裂症有关联,但其潜在的生物学机制仍然难以捉摸。本研究探讨了血浆催产素在童年创伤与精神分裂症精神病理学之间的潜在中介作用。研究人员使用童年创伤问卷和结构化访谈对 160 名精神分裂症患者和 80 名年龄和性别匹配的健康对照者的童年创伤经历进行了评估。心理病理学采用阳性和阴性综合量表进行评估,并测量血浆催产素水平。结果显示,与健康对照组相比,精神分裂症患者的催产素水平较低,童年创伤得分较高。童年创伤评分与精神病理学之间存在明显的相关性,除阳性症状外,血浆催产素水平与精神病理学成反比。层次回归分析表明,童年创伤得分和血浆催产素水平都能显著预测精神病理学。血浆催产素水平在一定程度上介导了童年创伤与精神分裂症精神病理学之间的关系。这项研究强调了催产素在弥合童年创伤与精神分裂症之间的潜在作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Linking childhood trauma to the psychopathology of schizophrenia: the role of oxytocin.

Linking childhood trauma to the psychopathology of schizophrenia: the role of oxytocin.

Childhood trauma has been linked to schizophrenia, but underlying biological mechanisms remain elusive. This study explored the potential role of plasma oxytocin as a mediator in the relationship between childhood trauma and the psychopathology of schizophrenia. 160 patients with schizophrenia and 80 age- and sex-matched healthy controls were assessed for childhood trauma experiences using the Childhood Trauma Questionnaire and structured interviews. Psychopathology was evaluated using the Positive and Negative Syndrome Scale and plasma oxytocin levels were measured. Results showed that patients with schizophrenia had lower oxytocin levels and higher childhood trauma scores than healthy controls. There was a significant correlation between childhood trauma scores and psychopathology, with plasma oxytocin levels being inversely associated with psychopathology, except for positive symptoms. Hierarchical regression analysis indicated that both childhood trauma scores and plasma oxytocin levels significantly predicted psychopathology. Plasma oxytocin levels partially mediated the relationship between childhood trauma and schizophrenia psychopathology. This study underscores the potential role of oxytocin in bridging the gap between childhood trauma and schizophrenia.

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