基于自然杀伤细胞的特征:头颈部鳞状细胞癌的预后分析。

IF 3.2 4区 医学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Zizhao Guo, Yuxia Zhao, Meng Xu, Long Zhao, Xiaolei Wang
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引用次数: 0

摘要

背景:头颈部鳞状细胞癌(HNSC)是一种具有重大临床影响的挑战性癌症。自然杀伤(NK)细胞已成为肿瘤免疫监视的重要参与者,但它们在 HNSC 中作为预后生物标志物的作用和潜力仍不清楚:方法:使用多种算法进行定量分析,发现FCRL1、KIR3DL2和ZNF541是与局部NK细胞浸润和患者生存显著相关的分子。基于这些分子的预后模型显示出强大的预测能力:结果:对高危和低危患者组的分析显示肿瘤微环境存在明显差异,表明高危患者的免疫微环境具有抑制性。值得注意的是,低危患者对免疫疗法表现出潜在的敏感性,并对阿西替尼、甲氨蝶呤、雷帕霉素和伏立诺他等特定药物表现出良好的反应。研究发现,先天性免疫反应的重要效应因子NK细胞在HNSC免疫中发挥着关键作用。本研究就 FCRL1、KIR3DL2、ZNF541 和 NK 细胞浸润之间的相关性提供了有价值的见解,为今后研究它们在 HNSC 中的作用铺平了道路。在高危患者中,NOTCH信号、MYC靶点、DNA修复、E2F靶点、上皮-间质转化、G2M检查点和有丝分裂纺锤体通路的激活表明它们参与了疾病的进展和不良预后:本研究揭示了 NK 细胞在 HNSC 中的重要性及其作为预后生物标志物的潜力。CFKZ 评分为预测 HNSC 患者的预后和指导个性化治疗决策提供了一种有前景的方法。这些发现有助于我们了解 HNSC 免疫生物学,并对 HNSC 治疗中的精准医疗具有重要意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Natural killer cell-based signature: Prognostic analysis in head and neck squamous cell carcinoma

Natural killer cell-based signature: Prognostic analysis in head and neck squamous cell carcinoma

Background

Head and neck squamous cell carcinoma (HNSC) is a challenging cancer with significant clinical implications. Natural killer (NK) cells have emerged as important players in tumor immunosurveillance, yet their role and potential as prognostic biomarkers in HNSC remain unclear.

Methods

Quantitative analysis using multiple algorithms identified FCRL1, KIR3DL2 and ZNF541 as molecules significantly associated with local NK cell infiltration and patient survival. A prognostic model based on these molecules demonstrated robust predictive performance.

Results

Analysis of high- and low-risk patient groups revealed distinct differences in the tumor microenvironment, indicating an inhibitory immune microenvironment in high-risk patients. Notably, low-risk patients exhibited potential sensitivity to immunotherapy and showed favorable responses to specific drugs such as axitinib, methotrexate, rapamycin and vorinostat. NK cells, important effectors of the innate immune response, were found to play a crucial role in HNSC immunity. The present study provides valuable insights into the correlation between FCRL1, KIR3DL2, ZNF541 and NK cell infiltration, paving the way for future investigations into their roles in HNSC. Activation of NOTCH signaling, MYC targets, DNA repair, E2F targets, epithelial–mesenchymal transition, G2M checkpoint and mitotic spindle pathways in high-risk patients suggests their involvement in disease progression and poor prognosis.

Conclusions

The present study reveals the significance of NK cells in HNSC and their potential as prognostic biomarkers. The CFKZ score offers a promising approach for predicting patient outcomes and guiding personalized treatment decisions in HNSC. These findings contribute to our understanding of HNSC immunobiology and hold implications for precision medicine in HNSC management.

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来源期刊
Journal of Gene Medicine
Journal of Gene Medicine 医学-生物工程与应用微生物
CiteScore
6.40
自引率
0.00%
发文量
80
审稿时长
6-12 weeks
期刊介绍: The aims and scope of The Journal of Gene Medicine include cutting-edge science of gene transfer and its applications in gene and cell therapy, genome editing with precision nucleases, epigenetic modifications of host genome by small molecules, siRNA, microRNA and other noncoding RNAs as therapeutic gene-modulating agents or targets, biomarkers for precision medicine, and gene-based prognostic/diagnostic studies. Key areas of interest are the design of novel synthetic and viral vectors, novel therapeutic nucleic acids such as mRNA, modified microRNAs and siRNAs, antagomirs, aptamers, antisense and exon-skipping agents, refined genome editing tools using nucleic acid /protein combinations, physically or biologically targeted delivery and gene modulation, ex vivo or in vivo pharmacological studies including animal models, and human clinical trials. Papers presenting research into the mechanisms underlying transfer and action of gene medicines, the application of the new technologies for stem cell modification or nucleic acid based vaccines, the identification of new genetic or epigenetic variations as biomarkers to direct precision medicine, and the preclinical/clinical development of gene/expression signatures indicative of diagnosis or predictive of prognosis are also encouraged.
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