有害微量元素环境暴露与肺功能综合分析:一项全国性横断面研究。

IF 9 1区 医学 Q1 RESPIRATORY SYSTEM
Thorax Pub Date : 2024-06-14 DOI:10.1136/thorax-2022-219839
Yun-Jiang Yu, Tong Zheng, Jennifer L Perret, Yajing Han, Hongyan Li, Wenjie Meng, Dinh Bui, Qi-Zhen Wu, Chenyin Dong, Qiu-Ling Fang, Zhenchi Li, Hongxuan Kuang, Xiaowen Chen, Mingdeng Xiang, Xiaodi Qin, Shyamali C Dharmage, Guang-Hui Dong, Yang Zhou
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引用次数: 0

摘要

背景:人们对有害微量元素(HTEs)对肺功能缺陷的共同影响越来越感兴趣,但相关数据却很有限。鉴于全球工业化程度的提高,这是一个关键的研究缺口:方法:2020 年至 2021 年期间,在中国 11 个省的 2112 名成年人中开展了一项包括肺活量测定在内的全国性横断面研究。从尿液样本中共量化了 27 种 HTE。研究采用广义线性模型和基于量纲的g计算方法,分别探讨了尿液中HTEs对肺功能的个体影响和联合影响:总体而言,1 秒用力呼气容积(FEV1)与尿砷(As)(z-score coefficient,-0.150;95% CI,-0.262 至 -0.038,每增加 1 ln-单位)、钡(Ba)(-0.148,95% CI:-0.258至-0.039)、镉(Cd)(-0.132,95% CI:-0.236至-0.028)、铊(Tl)(-0.137,95% CI:-0.257至-0.018)、锶(Sr)(-0.147,95% CI:-0.273至-0.022)和铅(Pb)(-0.121,95% CI:-0.219至-0.023)。尿液中的砷、钡和铅以及钛(Ti)、砷、锶、镉、碲和铅对用力呼吸容量(FVC)和 FEV1/FVC 的影响也有类似的结果。我们发现,关节 HTE 的 ln-quartile 值与 FEV1(-20 mL,95% CI:-48 至 +8)和 FVC(-14 mL,95% CI:-49 至 +2)下降之间存在边缘关联。在模型中,Ba 和 Ti 分别被赋予 FEV1 和 FVC 的最大负权重:我们在高污染环境中对各种 HTE 进行的研究表明,尿液中 HTE 浓度越高,肺功能越差,尤其是新出现的 Ti 和 Ba,需要对其进行监测或调节,以改善肺部健康。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comprehensive analysis of environmental exposure to hazardous trace elements and lung function: a national cross-sectional study.

Background: There is growing interest in the joint effects of hazardous trace elements (HTEs) on lung function deficits, but the data are limited. This is a critical research gap given increased global industrialisation.

Methods: A national cross-sectional study including spirometry was performed among 2112 adults across 11 provinces in China between 2020 and 2021. A total of 27 HTEs were quantified from urine samples. Generalised linear models and quantile-based g-computation were used to explore the individual and joint effects of urinary HTEs on lung function, respectively.

Results: Overall, there were negative associations between forced expiratory volume in 1 s (FEV1) and urinary arsenic (As) (z-score coefficient, -0.150; 95% CI, -0.262 to -0.038 per 1 ln-unit increase), barium (Ba) (-0.148, 95% CI: -0.258 to -0.039), cadmium (Cd) (-0.132, 95% CI: -0.236 to -0.028), thallium (Tl) (-0.137, 95% CI: -0.257 to -0.018), strontium (Sr) (-0.147, 95% CI: -0.273 to -0.022) and lead (Pb) (-0.121, 95% CI: -0.219 to -0.023). Similar results were observed for forced vital capacity (FVC) with urinary As, Ba and Pb and FEV1/FVC with titanium (Ti), As, Sr, Cd, Tl and Pb. We found borderline associations between the ln-quartile of joint HTEs and decreased FEV1 (-20 mL, 95% CI: -48 to +8) and FVC (-14 mL, 95% CI: -49 to+2). Ba and Ti were assigned the largest negative weights for FEV1 and FVC within the model, respectively.

Conclusion: Our study investigating a wide range of HTEs in a highly polluted setting suggests that higher urinary HTE concentrations are associated with lower lung function, especially for emerging Ti and Ba, which need to be monitored or regulated to improve lung health.

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来源期刊
Thorax
Thorax 医学-呼吸系统
CiteScore
16.10
自引率
2.00%
发文量
197
审稿时长
1 months
期刊介绍: Thorax stands as one of the premier respiratory medicine journals globally, featuring clinical and experimental research articles spanning respiratory medicine, pediatrics, immunology, pharmacology, pathology, and surgery. The journal's mission is to publish noteworthy advancements in scientific understanding that are poised to influence clinical practice significantly. This encompasses articles delving into basic and translational mechanisms applicable to clinical material, covering areas such as cell and molecular biology, genetics, epidemiology, and immunology.
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