动脉血栓研究微流控技术的最新进展。

IF 2.5 3区 医学 Q3 CELL BIOLOGY
Platelets Pub Date : 2024-12-01 Epub Date: 2024-02-23 DOI:10.1080/09537104.2024.2316743
Jingying Lin, Si Chen, Chunying Zhang, Juan Liao, Yuemei Chen, Shanying Deng, Zhigang Mao, Tonghao Zhang, Na Tian, Yali Song, Tingting Zeng
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引用次数: 0

摘要

微流控技术已成为研究动脉血栓形成的有力工具,它使研究人员能够构建人造血管并复制血液流动的血流动力学。这项技术在理解血栓形成和血小板粘附与聚集方面取得了重大进展。微流控模型有多种类型和功能,通过研究微流控芯片的制作方法和工作原理,可以根据具体需要选择适用的方法。微流控集成系统和模块化微流控系统的快速发展使动脉血栓研究更加多样化和自动化,但其标准化问题仍亟待解决。微流控技术的一个主要优势是能够精确控制微通道中的流体流动,分析不同剪切力和流速下的血小板行为。这使研究人员能够研究血流的生理和病理过程,揭示动脉血栓形成的内在机制。总之,微流控技术实现了人造血管的构建和血液动力学的精确再现,为动脉血栓研究带来了革命性的变化。未来,微流控技术将更加注重多功能性和自动化,在推进抗血栓治疗和预防措施方面大有可为。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Recent advances in microfluidic technology of arterial thrombosis investigations.

Microfluidic technology has emerged as a powerful tool in studying arterial thrombosis, allowing researchers to construct artificial blood vessels and replicate the hemodynamics of blood flow. This technology has led to significant advancements in understanding thrombosis and platelet adhesion and aggregation. Microfluidic models have various types and functions, and by studying the fabrication methods and working principles of microfluidic chips, applicable methods can be selected according to specific needs. The rapid development of microfluidic integrated system and modular microfluidic system makes arterial thrombosis research more diversified and automated, but its standardization still needs to be solved urgently. One key advantage of microfluidic technology is the ability to precisely control fluid flow in microchannels and to analyze platelet behavior under different shear forces and flow rates. This allows researchers to study the physiological and pathological processes of blood flow, shedding light on the underlying mechanisms of arterial thrombosis. In conclusion, microfluidic technology has revolutionized the study of arterial thrombosis by enabling the construction of artificial blood vessels and accurately reproducing hemodynamics. In the future, microfluidics will place greater emphasis on versatility and automation, holding great promise for advancing antithrombotic therapeutic and prophylactic measures.

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来源期刊
Platelets
Platelets 医学-细胞生物学
CiteScore
6.70
自引率
3.00%
发文量
79
审稿时长
1 months
期刊介绍: Platelets is an international, peer-reviewed journal covering all aspects of platelet- and megakaryocyte-related research. Platelets provides the opportunity for contributors and readers across scientific disciplines to engage with new information about blood platelets. The journal’s Methods section aims to improve standardization between laboratories and to help researchers replicate difficult methods. Research areas include: Platelet function Biochemistry Signal transduction Pharmacology and therapeutics Interaction with other cells in the blood vessel wall The contribution of platelets and platelet-derived products to health and disease The journal publishes original articles, fast-track articles, review articles, systematic reviews, methods papers, short communications, case reports, opinion articles, commentaries, gene of the issue, and letters to the editor. Platelets operates a single-blind peer review policy. Authors can choose to publish gold open access in this journal.
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