子宫肌瘤和肉瘤的治疗:巴勒莫立场文件。

IF 2 4区 医学 Q2 OBSTETRICS & GYNECOLOGY
Gynecologic and Obstetric Investigation Pub Date : 2024-01-01 Epub Date: 2024-02-21 DOI:10.1159/000537730
Antonio Simone Laganà, Andrea Romano, Arne Vanhie, Celine Bafort, Martin Götte, Lauri A Aaltonen, Aymara Mas, Christine De Bruyn, Thierry Van den Bosch, An Coosemans, Stefano Guerriero, Sergio Haimovich, Vasilios Tanos, Marlies Bongers, Fabio Barra, Ayman Al-Hendy, Vito Chiantera, Umberto Leone Roberti Maggiore
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引用次数: 0

摘要

背景 子宫肌瘤是起源于子宫肌层平滑肌细胞的单克隆良性肿瘤,是女性生殖道中最常见的病变。子宫肉瘤虽然罕见,但仍是诊断上的难题,应在具备妇科肿瘤学专业知识的中心进行治疗。本文旨在总结和讨论子宫肌瘤和子宫肉瘤诊断和治疗的前沿要点。方法 本文是 2023 年 2 月在巴勒莫举行的子宫肌瘤和肉瘤专家会议的演讲报告。结果 总体而言,新型分子途径的结合可能有助于将生物标记物和专家超声结合起来,对子宫肌瘤和肉瘤进行鉴别诊断。一方面,与组织学分析和全组织转录组学相比,子宫肌瘤和匹配子宫肌层的分子和细胞图谱可提高我们对肿瘤发生发展的认识,并支持微创治疗策略的开发;另一方面,超声成像可在大多数情况下正确绘制肌瘤图谱,并区分良性和恶性病变,这需要适当的管理。结论与展望 子宫肌瘤治疗方法的选择,包括药物治疗、手术治疗或其他策略,如高强度聚焦超声(HIFU),应根据患者的特点和生殖预后仔细考虑。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Management of Uterine Fibroids and Sarcomas: The Palermo Position Paper.

Background: Uterine fibroids are benign monoclonal tumors originating from the smooth muscle cells of the myometrium, constituting the most prevalent pathology within the female genital tract. Uterine sarcomas, although rare, still represent a diagnostic challenge and should be managed in centers with adequate expertise in gynecological oncology.

Objectives: This article is aimed to summarize and discuss cutting-edge elements about the diagnosis and management of uterine fibroids and sarcomas.

Methods: This paper is a report of the lectures presented in an expert meeting about uterine fibroids and sarcomas held in Palermo in February 2023.

Outcome: Overall, the combination of novel molecular pathways may help combine biomarkers and expert ultrasound for the differential diagnosis of uterine fibroids and sarcomas. On the one hand, molecular and cellular maps of uterine fibroids and matched myometrium may enhance our understanding of tumor development compared to histologic analysis and whole tissue transcriptomics, and support the development of minimally invasive treatment strategies; on the other hand, ultrasound imaging allows in most of the cases a proper mapping the fibroids and to differentiate between benign and malignant lesions, which need appropriate management.

Conclusions and outlook: The choice of uterine fibroid management, including pharmacological approaches, surgical treatment, or other strategies, such as high-intensity focused ultrasound (HIFU), should be carefully considered, taking into account the characteristics of the patient and reproductive prognosis.

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来源期刊
CiteScore
4.20
自引率
4.80%
发文量
44
审稿时长
6-12 weeks
期刊介绍: This journal covers the most active and promising areas of current research in gynecology and obstetrics. Invited, well-referenced reviews by noted experts keep readers in touch with the general framework and direction of international study. Original papers report selected experimental and clinical investigations in all fields related to gynecology, obstetrics and reproduction. Short communications are published to allow immediate discussion of new data. The international and interdisciplinary character of this periodical provides an avenue to less accessible sources and to worldwide research for investigators and practitioners.
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