一个微不足道的建议:将αv整合素介导的潜伏TGFbeta激活作为治疗硬皮病纤维化的新疗法。

IF 4.9 2区 医学 Q1 PHARMACOLOGY & PHARMACY
Andrew Leask, Asmaa Fadl, Angha Naik
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引用次数: 0

摘要

导言:强效促组织坏死细胞因子转化生长因子-β(TGF-β)与自身免疫性结缔组织疾病硬皮病(系统性硬化症,SSc)纤维化的发生和发展有关:本综述探讨了支持TGF-β导致SSc纤维化这一观点的数据,并研究了为什么针对整合素介导的潜伏TGF-β激活启动SSc临床试验正当其时:专家观点:直接靶向 TGF-β 对该病的临床疗效尚未得到证实。相反,以基质僵化为靶点可能更有希望,因为基质僵化会使纤维化长期存在。有趣的是,以整合素介导的潜伏 TGF-β 激活为靶点可能具有治疗价值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A modest proposal: targeting αv integrin-mediated activation of latent TGFbeta as a novel therapeutic approach to treat scleroderma fibrosis.

Introduction: The potent profibrotic cytokine transforming growth factor-β (TGF-β) has been associated with the onset and progression of the fibrosis seen in the autoimmune connective tissue disease scleroderma (systemic sclerosis, SSc).

Area covered: This review explores the data supporting the notion that TGF-β contributes to SSc fibrosis and examines why initiating clinical trials in SSc aimed at targeting integrin-mediated latent TGF-β activation is timely.

Expert opinion: Targeting TGF-β directly has not been proven to be clinically effective in this disease. Conversely, targeting matrix stiffness, which perpetuates fibrosis, may have more promise. Intriguingly, targeting integrin-mediated activation of latent TGF-β, which bridges these concepts, may have therapeutic value.

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来源期刊
CiteScore
10.00
自引率
0.00%
发文量
71
审稿时长
6-12 weeks
期刊介绍: Expert Opinion on Investigational Drugs (ISSN 1354-3784 [print], 1744-7658 [electronic]) is a MEDLINE-indexed, peer-reviewed, international journal publishing review articles and original papers on drugs in preclinical and early stage clinical development, providing expert opinion on the scope for future development. The Editors welcome: Reviews covering preclinical through to Phase II data on drugs or drug classes for specific indications, and their potential impact on future treatment strategies Drug Evaluations reviewing the clinical and pharmacological data on a particular drug Original Research papers reporting the results of clinical investigations on agents that are in Phase I and II clinical trials The audience consists of scientists, managers and decision-makers in the pharmaceutical industry, and others closely involved in R&D.
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