Xiaoyan Zhu , Fei Liang , Jieyun Yin , Xiaoliang Li , Lai Jiang , Yan Gao , Yan Lu , Yihe Hu , Ningbin Dai , Jian Su , Zhuoqiao Yang , Mengxin Yao , Yue Xiao , Wenxin Ge , Yue Zhang , Yi Zhong , Jun Zhang , Ming Wu
{"title":"2 型糖尿病患者血浆 IGFBP7 水平与糖尿病并发症持续时间的关系","authors":"Xiaoyan Zhu , Fei Liang , Jieyun Yin , Xiaoliang Li , Lai Jiang , Yan Gao , Yan Lu , Yihe Hu , Ningbin Dai , Jian Su , Zhuoqiao Yang , Mengxin Yao , Yue Xiao , Wenxin Ge , Yue Zhang , Yi Zhong , Jun Zhang , Ming Wu","doi":"10.1016/j.ghir.2024.101574","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>Insulin-like growth factor binding protein 7 (IGFBP7) has a strong affinity to insulin. This study aimed to evaluate the relationship between IGFBP7 and complications among type 2 diabetes mellitus (T2DM) patients.</p></div><div><h3>Design</h3><p>A total of 1449 T2DM patients were selected from a cross-sectional study for disease management registered in the National Basic Public Health Service in Changshu, China, and further tested for their plasma IGFBP7 levels. Logistic regressions and Spearman's rank correlation analyses were used to explore the associations of IGFBP7 with diabetic complications and clinical characteristics, respectively.</p></div><div><h3>Results</h3><p>Among the 1449 included T2DM patients, 403 (27.81%) had complications. In patients with shorter duration (less than five years), the base 10 logarithms of IGFBP7 concentration were associated with T2DM complications, with an adjusted odds ratio (OR) of 2.41 [95% confidence interval (95%CI) = 1.06–5.48]; while in patients with longer duration (more than five years), plasma IGFBP7 levels were not associated with T2DM complications. Furthermore, in T2DM patients with shorter duration, those with two or more types of complications were more likely to have higher levels of IGFBP7.</p></div><div><h3>Conclusion</h3><p>IGFBP7 is positively associated with the risk of complication in T2DM patients with shorter duration.</p></div>","PeriodicalId":12803,"journal":{"name":"Growth Hormone & Igf Research","volume":"75 ","pages":"Article 101574"},"PeriodicalIF":1.6000,"publicationDate":"2024-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Duration-specific association between plasma IGFBP7 levels and diabetic complications in patients with type 2 diabetes mellitus\",\"authors\":\"Xiaoyan Zhu , Fei Liang , Jieyun Yin , Xiaoliang Li , Lai Jiang , Yan Gao , Yan Lu , Yihe Hu , Ningbin Dai , Jian Su , Zhuoqiao Yang , Mengxin Yao , Yue Xiao , Wenxin Ge , Yue Zhang , Yi Zhong , Jun Zhang , Ming Wu\",\"doi\":\"10.1016/j.ghir.2024.101574\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><p>Insulin-like growth factor binding protein 7 (IGFBP7) has a strong affinity to insulin. This study aimed to evaluate the relationship between IGFBP7 and complications among type 2 diabetes mellitus (T2DM) patients.</p></div><div><h3>Design</h3><p>A total of 1449 T2DM patients were selected from a cross-sectional study for disease management registered in the National Basic Public Health Service in Changshu, China, and further tested for their plasma IGFBP7 levels. Logistic regressions and Spearman's rank correlation analyses were used to explore the associations of IGFBP7 with diabetic complications and clinical characteristics, respectively.</p></div><div><h3>Results</h3><p>Among the 1449 included T2DM patients, 403 (27.81%) had complications. In patients with shorter duration (less than five years), the base 10 logarithms of IGFBP7 concentration were associated with T2DM complications, with an adjusted odds ratio (OR) of 2.41 [95% confidence interval (95%CI) = 1.06–5.48]; while in patients with longer duration (more than five years), plasma IGFBP7 levels were not associated with T2DM complications. Furthermore, in T2DM patients with shorter duration, those with two or more types of complications were more likely to have higher levels of IGFBP7.</p></div><div><h3>Conclusion</h3><p>IGFBP7 is positively associated with the risk of complication in T2DM patients with shorter duration.</p></div>\",\"PeriodicalId\":12803,\"journal\":{\"name\":\"Growth Hormone & Igf Research\",\"volume\":\"75 \",\"pages\":\"Article 101574\"},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2024-02-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Growth Hormone & Igf Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1096637424000042\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Growth Hormone & Igf Research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1096637424000042","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
Duration-specific association between plasma IGFBP7 levels and diabetic complications in patients with type 2 diabetes mellitus
Objective
Insulin-like growth factor binding protein 7 (IGFBP7) has a strong affinity to insulin. This study aimed to evaluate the relationship between IGFBP7 and complications among type 2 diabetes mellitus (T2DM) patients.
Design
A total of 1449 T2DM patients were selected from a cross-sectional study for disease management registered in the National Basic Public Health Service in Changshu, China, and further tested for their plasma IGFBP7 levels. Logistic regressions and Spearman's rank correlation analyses were used to explore the associations of IGFBP7 with diabetic complications and clinical characteristics, respectively.
Results
Among the 1449 included T2DM patients, 403 (27.81%) had complications. In patients with shorter duration (less than five years), the base 10 logarithms of IGFBP7 concentration were associated with T2DM complications, with an adjusted odds ratio (OR) of 2.41 [95% confidence interval (95%CI) = 1.06–5.48]; while in patients with longer duration (more than five years), plasma IGFBP7 levels were not associated with T2DM complications. Furthermore, in T2DM patients with shorter duration, those with two or more types of complications were more likely to have higher levels of IGFBP7.
Conclusion
IGFBP7 is positively associated with the risk of complication in T2DM patients with shorter duration.
期刊介绍：
Growth Hormone & IGF Research is a forum for research on the regulation of growth and metabolism in humans, animals, tissues and cells. It publishes articles on all aspects of growth-promoting and growth-inhibiting hormones and factors, with particular emphasis on insulin-like growth factors (IGFs) and growth hormone. This reflects the increasing importance of growth hormone and IGFs in clinical medicine and in the treatment of diseases.
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