结核分枝杆菌的所有 VapC 毒素都具有神秘的 RNase 活性吗？

IF 2.1 4区生物学 Q2 BIOLOGY

Journal of Biosciences Pub Date : 2024-02-19 DOI:10.1007/s12038-024-00420-3

Sheeba Zarin, Anwar Alam, Seyed Ehtesham Hasnain, Nasreen Zafar Ehtesham

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引用次数: 0

摘要

结核分枝杆菌（Mycobacterium tuberculosis，M. tb）拥有一个由 90 多种毒素-抗毒素系统组成的广泛网络，其中 VapC 毒素最为丰富。虽然大多数 VapC 具有典型的 RNase 功能，具有毒性作用，但也有相当数量的 VapC 没有毒性。然而，这些无毒的 VapCs 可能会保留特定的 RNA 结合能力，如 VapC16 所示，从而导致核糖体在特定密码子处停滞，并重塑 M. tb 的蛋白质组，帮助该细菌在宿主体内不同的应激条件下生存。在这里，我们对将所有 VapC 毒素都归类为 RN 酶的传统观点提出了质疑，并强调了 M. tb 在感染期间生存和适应策略的复杂性。

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Are all VapC toxins of Mycobacterium tuberculosis endowed with enigmatic RNase activity?

Mycobacterium tuberculosis (M. tb) employs an extensive network of more than 90 toxin–antitoxin systems, and among them, VapC toxins are the most abundant. While most VapCs function as classical RNases with toxic effects, a significant number of them do not exhibit toxicity. However, these non-toxic VapCs may retain specific RNA binding abilities as seen in case of VapC16, leading to ribosome stalling at specific codons and reprofiling M. tb's proteome to aid in the bacterium's survival under different stressful conditions within the host. Here, we challenge the conventional classification of all VapC toxins as RNases and highlight the complexity of M. tb's strategies for survival and adaptation during infection.

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来源期刊

Journal of Biosciences 生物-生物学

CiteScore

5.80

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： The Journal of Biosciences is a quarterly journal published by the Indian Academy of Sciences, Bangalore. It covers all areas of Biology and is the premier journal in the country within its scope. It is indexed in Current Contents and other standard Biological and Medical databases. The Journal of Biosciences began in 1934 as the Proceedings of the Indian Academy of Sciences (Section B). This continued until 1978 when it was split into three parts : Proceedings-Animal Sciences, Proceedings-Plant Sciences and Proceedings-Experimental Biology. Proceedings-Experimental Biology was renamed Journal of Biosciences in 1979; and in 1991, Proceedings-Animal Sciences and Proceedings-Plant Sciences merged with it.