呼出硫化氢在诊断结直肠癌中的作用。

IF 3.3 Q2 GASTROENTEROLOGY & HEPATOLOGY
Peizhun Du, Yujen Tseng, Pengcheng Liu, Huilu Zhang, Guangjian Huang, Cheng'en Hu, Jian Chen
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引用次数: 0

摘要

背景:大肠癌(CRC)通常伴有硫化氢(H2S)排泄增加。本研究旨在探讨呼出的 H2S 在诊断 CRC 中的价值:本观察性队列研究共纳入了 80 名结肠镜检查结果正常者和 57 名 CRC 患者。采用 Nanocoulomb 呼气分析仪检测口腔和鼻腔呼出的 H2S。两组结果进行了比较。分析了接收者操作特征曲线(ROC),并计算了曲线下面积(AUC),以评估呼出的 H2S 的诊断价值。同时,还收集并分析了 CRC 患者的临床病理特征,包括性别、病变部位和肿瘤分期:结果:CRC 患者呼出的 H2S 量明显高于结肠镜检查结果正常的患者。根据口腔和鼻腔 H2S 检测结果,ROC 曲线的 AUC 值分别为 0.73 和 0.71。结论:CRC 患者呼出的 H2S 与性别、病灶位置和肿瘤进展(包括侵犯深度、淋巴转移和 TNM(肿瘤、淋巴结、转移)分期)相关:结论:呼出的 H2S 分析是诊断 CRC 的一种方便、无创的检测方法,它在人群 CRC 筛查中具有潜在的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Role of exhaled hydrogen sulfide in the diagnosis of colorectal cancer.

Background: Colorectal cancer (CRC) is often accompanied by increased excretion of hydrogen sulfide (H2S). This study aimed to explore the value of exhaled H2S in the diagnosis of CRC.

Methods: A total of 80 people with normal colonoscopy results and 57 patients with CRC were enrolled into the present observational cohort study. Exhaled oral and nasal H2S were detected by Nanocoulomb breath analyser. Results were compared between the two groups. Receiver operating characteristic (ROC) curves were analysed and area under the curves (AUCs) were calculated to assess the diagnostic value of exhaled H2S. Meanwhile, the clinicopathological features, including gender, lesion location and tumour staging of patients with CRC, were also collected and analysed.

Results: The amount of exhaled H2S from patients with CRC was significantly higher than that of those with normal colonoscopy results. The ROC curve showed an AUC value of 0.73 and 0.71 based on oral and nasal H2S detection, respectively. The exhaled H2S in patients with CRC was correlated with gender, lesion location and tumour progression, including depth of invasion, lymphatic metastasis and TNM (Tumor, Lymph Nodes, Metastasis) staging.

Conclusion: Exhaled H2S analysis is a convenient and non-invasive detection method for diagnosing CRC, suggesting a potential role in population screening for CRC.

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来源期刊
BMJ Open Gastroenterology
BMJ Open Gastroenterology GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
5.90
自引率
3.20%
发文量
68
审稿时长
2 weeks
期刊介绍: BMJ Open Gastroenterology is an online-only, peer-reviewed, open access gastroenterology journal, dedicated to publishing high-quality medical research from all disciplines and therapeutic areas of gastroenterology. It is the open access companion journal of Gut and is co-owned by the British Society of Gastroenterology. The journal publishes all research study types, from study protocols to phase I trials to meta-analyses, including small or specialist studies. Publishing procedures are built around continuous publication, publishing research online as soon as the article is ready.
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