衰老小胶质细胞在脑衰老相关神经退行性疾病中的新作用

IF 10.8 1区医学 Q1 NEUROSCIENCES

Translational Neurodegeneration Pub Date : 2024-02-20 DOI:10.1186/s40035-024-00402-3

Chan Rim, Min-Jung You, Minyeop Nahm, Min-Soo Kwon

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引用次数: 0

摘要

大脑衰老是阿尔茨海默病、帕金森病和肌萎缩性脊髓侧索硬化症（ALS，卢伽雷氏病）等神经退行性疾病的公认风险因素，但人们对大脑衰老与这些疾病的发病机制之间错综复杂的相互作用仍然缺乏足够的了解。细胞衰老被认为是导致细胞功能障碍和炎症的原因之一。根据衰老细胞积累的阈值理论，易患神经退行性疾病与大脑内衰老细胞的生成和清除率有关。鉴于小胶质细胞在清除衰老细胞方面的作用，衰老小胶质细胞的积累可能会导致大脑加速衰老，导致炎症和更易患神经退行性疾病。在这篇综述中，我们提出了这样一个观点：小胶质细胞的衰老对衰老具有显著的脆弱性，有可能成为神经退行性疾病进展的核心催化剂。衰老的小胶质细胞正在成为缓解神经退行性疾病的一个有希望的靶点。

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Emerging role of senescent microglia in brain aging-related neurodegenerative diseases

Brain aging is a recognized risk factor for neurodegenerative diseases like Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease), but the intricate interplay between brain aging and the pathogenesis of these conditions remains inadequately understood. Cellular senescence is considered to contribute to cellular dysfunction and inflammaging. According to the threshold theory of senescent cell accumulation, the vulnerability to neurodegenerative diseases is associated with the rates of senescent cell generation and clearance within the brain. Given the role of microglia in eliminating senescent cells, the accumulation of senescent microglia may lead to the acceleration of brain aging, contributing to inflammaging and increased vulnerability to neurodegenerative diseases. In this review, we propose the idea that the senescence of microglia, which is notably vulnerable to aging, could potentially serve as a central catalyst in the progression of neurodegenerative diseases. The senescent microglia are emerging as a promising target for mitigating neurodegenerative diseases.

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来源期刊

Translational Neurodegeneration Neuroscience-Cognitive Neuroscience

CiteScore

19.50

自引率

0.80%

发文量

审稿时长

10 weeks

期刊介绍： Translational Neurodegeneration, an open-access, peer-reviewed journal, addresses all aspects of neurodegenerative diseases. It serves as a prominent platform for research, therapeutics, and education, fostering discussions and insights across basic, translational, and clinical research domains. Covering Parkinson's disease, Alzheimer's disease, and other neurodegenerative conditions, it welcomes contributions on epidemiology, pathogenesis, diagnosis, prevention, drug development, rehabilitation, and drug delivery. Scientists, clinicians, and physician-scientists are encouraged to share their work in this specialized journal tailored to their fields.