以刚性双环支架为特征的 1,2,3-三唑亚基对映体中氧羰基 (MIC) 共轭酸的合成

IF 4.7 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Chemistry Frontiers Pub Date : 2024-02-20 DOI:10.1039/D4QO00269E

Vojtěch Dočekal, Mohand Melaimi, Simona Petrželová, Jan Veselý, Xiaoyu Yan and Guy Bertrand

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引用次数: 0

摘要

手性 NHC 作为过渡金属的配体以及其本身在不对称催化方面的应用已经非常广泛。在此，我们报告了一条合成对映体纯 1,2,3-三唑鎓（介离子碳烯共轭酸）的路线，其手性中心位于一个融合环中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Synthesis of enantiopure 1,2,3-triazolylidene-type mesoionic carbene (MIC) conjugate acids featuring a rigid bicyclic scaffold†

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Synthesis of enantiopure 1,2,3-triazolylidene-type mesoionic carbene (MIC) conjugate acids featuring a rigid bicyclic scaffold†

Chiral NHCs have found numerous applications as ligands for transition metals and in their own right for asymmetric catalysis. Here, we report a synthetic route from L-malic acid to enantiopure 1,2,3-triazoliums (mesoionic carbene conjugate acids) with a chiral center in a fused ring.

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来源期刊

Organic Chemistry Frontiers CHEMISTRY, ORGANIC-

CiteScore

7.90

自引率

11.10%

发文量

686

审稿时长

1 months

期刊介绍： Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.