单细胞分析揭示鼻咽癌和口咽癌的共性和异质性

IF 4.8 2区 医学 Q1 Biochemistry, Genetics and Molecular Biology
Liping Wang , Shuang Li , Xinran Li , Guangzheng Zhuo , Qian Zhang , Guohong Liu , Yunbao Pan
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引用次数: 0

摘要

鼻咽癌(NPC)和口咽癌(OPC)是头颈癌的亚型,由于肿瘤微环境的异质性,治疗效果也不尽相同。本研究旨在探讨鼻咽癌和口咽癌不同的肿瘤微环境。通过分析每种亚型的 10 个病例的单细胞数据,我们发现细胞组成存在显著差异,NPC 的微环境以 T/NK 和 B 细胞为主,而 OPC 则以上皮细胞和成纤维细胞为主。在这两种肿瘤类型中都观察到了 CD8 T 细胞的动态转变,包括从幼稚到细胞毒性、增殖以及最终衰竭/耗竭状态的转变。此外,在发育后期,Tregs 在衰竭的同时也表现出更强的增殖能力。这些高度增殖的 T 细胞和 Tregs 表现出较高的糖酵解和乳酸代谢活性。此外,我们还探讨了糖酵解性恶性上皮细胞与这些增殖性 T 细胞之间的细胞间通讯。这些发现全面揭示了肿瘤微环境的异质性,为未来的治疗策略和靶向干预奠定了坚实的基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Single cell analysis unveils the commonality and heterogeneity between nasopharyngeal and oropharyngeal carcinoma

Nasopharyngeal carcinoma (NPC) and oropharyngeal carcinoma (OPC) are subtypes of head and neck cancer with different treatment effects due to the heterogeneity of tumor microenvironments. This study was to investigate the distinctive tumor microenvironments of NPC and OPC. Analyzing single-cell data from 10 cases of each subtype, we reveal significant differences in cellular composition, with NPC microenvironment dominated by T/NK and B cells, and OPC characterized by prevalent epithelial cells and fibroblasts. Dynamic transitions of CD8 T cells are observed in both tumor types, involving shifts from naivety to cytotoxicity, proliferation, and eventual exhaustion/exhausted states. Additionally, Tregs exhibit heightened proliferative abilities in later developmental stages, concomitant with exhaustion. These highly proliferative T cells and Tregs manifest elevated glycolysis and lactate metabolism activities. Furthermore, we explore intercellular communication between glycolytic malignant epithelial cells and these proliferative T cells. These findings offer comprehensive insights into the heterogeneity of tumor microenvironments and provide a solid foundation for future therapeutic strategies and targeted interventions.

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来源期刊
Neoplasia
Neoplasia 医学-肿瘤学
CiteScore
9.20
自引率
2.10%
发文量
82
审稿时长
26 days
期刊介绍: Neoplasia publishes the results of novel investigations in all areas of oncology research. The title Neoplasia was chosen to convey the journal’s breadth, which encompasses the traditional disciplines of cancer research as well as emerging fields and interdisciplinary investigations. Neoplasia is interested in studies describing new molecular and genetic findings relating to the neoplastic phenotype and in laboratory and clinical studies demonstrating creative applications of advances in the basic sciences to risk assessment, prognostic indications, detection, diagnosis, and treatment. In addition to regular Research Reports, Neoplasia also publishes Reviews and Meeting Reports. Neoplasia is committed to ensuring a thorough, fair, and rapid review and publication schedule to further its mission of serving both the scientific and clinical communities by disseminating important data and ideas in cancer research.
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