伊维菌素对胎盘滋养体的体外药效测试

IF 0.7 4区农林科学 Q3 VETERINARY SCIENCES

Acta veterinaria Hungarica Pub Date : 2024-02-15 Print Date: 2024-04-12 DOI:10.1556/004.2024.01023

Estefanía Sereno-Bruno, Lumila Fuchs, Jorge Oyhenart

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引用次数: 0

摘要

目前尚无治疗牛只感染原生动物胎生三尖单胞菌（TF）的推荐药物。伊维菌素被广泛用于治疗肠道寄生虫，对一些体外生长的原生动物有效。在此，我们研究了伊维菌素对 TF 菌株的有效性。滋养体在伊维菌素浓度不断增加的培养基中培养，24 小时后测定死亡率。伊维菌素杀死细胞的平均最大有效浓度（EC50）为 2.47 μg mL-1。对于适合全身治疗的制剂来说，伊维菌素的有效浓度相当高。不过，仍可考虑并测试对动物进行局部治疗以防治 TF。

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In vitro efficacy testing of ivermectin against Tritrichomonas foetus trophozoites.

There are no recommended drugs to treat cattle infected with the protozoan Tritrichomonas foetus (TF). Ivermectin, widely used in the treatment of intestinal parasites, was found effective against some protozoa growing in vitro. Here, its effectiveness against a TF line was investigated. Trophozoites were incubated in media with increasing concentrations of ivermectin and mortality was determined after 24 h. Ivermectin killed cells with a mean maximum effective concentration (EC50) of 2.47 μg mL-1. The effective concentration of ivermectin was rather high for a formulation suitable for systemic treatment. However, topical treatment of animals against TF could still be considered and tested.

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来源期刊

Acta veterinaria Hungarica 农林科学-兽医学

CiteScore

1.80

自引率

0.00%

发文量

审稿时长

>36 weeks

期刊介绍： Acta Veterinaria Hungarica publishes original research papers presenting new scientific results of international interest, and to a limited extent also review articles and clinical case reports, on veterinary physiology (physiological chemistry and metabolism), veterinary microbiology (bacteriology, virology, immunology, molecular biology), on the infectious diseases of domestic animals, on veterinary parasitology, pathology, clinical veterinary science and reproduction.