A. R. Moravejolahkami, A. Chitsaz, Akbar Hassanzadeh, Z. Paknahad
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引用次数: 0
摘要
背景:多项研究强调了饮食调整与多发性硬化症(MS)相关残疾之间的关系。目的:确定同时摄入富含抗炎抗氧化剂的饮食和益生元是否能改善进展期多发性硬化症患者的临床表现。方法:研究涉及 70 名进展期多发性硬化症患者(原发性进展期、继发性进展期和进展期复发),他们被随机分配接受干预(合生元胶囊加富含抗炎抗氧化剂的饮食)或安慰剂。对随访前后的生活质量(QOL)、残疾状况扩展量表(EDSS)和抑郁焦虑评分进行了评估。最终分析采用协方差分析法(SPSS v.14)。结果:干预四个月后,EDSS(2.6±1.1 到 2.4±1.0,P < 0.001)、状态焦虑量表(53.7±10.3 到 47.8±10.6,P < 0.001)和 QOL 评分均有显著下降。抑郁严重程度无明显差异(干预组Δ = -2.2±5.5 vs. 对照组Δ = -0.6±5.7; P = 0.264)。结论:这项研究表明,合生元与饮食相结合是一种很有前景的策略,可改善进行性多发性硬化症的严重程度和临床表现。
Co-supplementation of synbiotics and anti-inflammatory-antioxidant rich diet in patients with progressive forms of multiple sclerosis: A single-center, randomized clinical trial
BACKGROUND: The relationship between dietary modification and Multiple Sclerosis (MS)-related disability has been emphasized in several researches. AIMS: To determine whether a co-administration of anti-inflammatory-antioxidant rich diet and synbiotics might improve clinical manifestations in progressive MS patients. METHODS: The study involved 70 patients with progressive MS (primary-progressive, secondary-progressive, and progressive-relapsing) who were randomized to receive either intervention (synbiotics capsule plus an anti-inflammatory-antioxidant-rich diet) or placebo. Quality of Life (QOL), Expanded Disability Status Scale (EDSS), and depression-anxiety scores were evaluated before and after the follow-up. Analysis of covariance was performed for final analysis (SPSS v.14). RESULTS: Significant reductions were seen in EDSS (2.6±1.1 to 2.4±1.0, P < 0.001), State Anxiety Inventory (53.7±10.3 to 47.8±10.6, P < 0.001), and QOL scores after four months of intervention. No significant difference was seen across the depression severity (Δ for intervention = –2.2±5.5 vs. Δ for control = –0.6±5.7; P = 0.264). CONCLUSION: This study demonstrates that a combination of synbiotics and diet could be a promising strategy to improve severity and clinical manifestations of progressive MS.