白花蛇舌草对癫痫状态的影响：临床前研究

Q4 Pharmacology, Toxicology and Pharmaceutics

Journal of Natural Remedies Pub Date : 2024-02-01 DOI:10.18311/jnr/2024/34983

Gayatri R. Nayak, Amrita Parida, Shreya Hegde, Smita Shenoy, K. G. Mohandas Rao, K. Shivakumar Reddy, V. Manju

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引用次数: 0

摘要

本研究采用锂-匹罗卡品癫痫状态（SE）模型，评估了白花蛇舌草种子油及其与丙戊酸钠的复方制剂对 Wistar 白化大鼠的抗惊厥作用。实验组包括I 组--正常对照组；II 组--疾病对照组；III 组--白花蛇舌草籽油；IV 组--丙戊酸钠；V 组--白花蛇舌草籽油 + ½ 剂量丙戊酸钠。对脑样本中的抗氧化标记物和脑源性神经营养因子（BDNF）水平进行了测定。此外，还使用甲酚紫染色法确定了病理变化。白花蛇舌草油并不能防止大鼠出现癫痫状态，但能降低癫痫的强度和发生频率。鸦胆子油还能提高抗氧化剂水平，降低过氧化脂质水平。在癫痫状态模型中，白花蛇舌草油和丙戊酸钠的组合显示出协同作用。研究结果表明，白花蛇舌草油可与其他抗癫痫药物一起用作癫痫状态的辅助药物。

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Sinapis alba ln Status Epilepticus: A Preclinical Study

In this study, the anti-convulsant effect of Sinapis alba seed oil and its combination with sodium valproate was evaluated in Wistar albino rats using the lithium-pilocarpine Status Epilepticus (SE) model. The experimental groups included: Group I - normal control; Group II - disease control; Group III - Sinapis alba seed oil; Group IV - sodium valproate; Group V - Sinapis alba seed oil + ½ dose sodium valproate. Antioxidant markers and Brain-Derived Neurotrophic Factor (BDNF) levels were measured from the brain samples. The pathological changes were also determined using Cresyl violet staining. Sinapis alba oil did not prevent rats from developing status epilepticus but reduced the intensity and frequency of occurrence. Oil administration increased antioxidant levels and decreased lipid peroxide levels as well. The combination of oil and sodium valproate showed a synergistic effect in the status epilepticus model. The study results show that Sinapis alba can be used as an adjuvant in status epilepticus along with other antiepileptic drugs.

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来源期刊

Journal of Natural Remedies Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

0.40

自引率

0.00%

发文量

期刊介绍： Nature can provide all the remedies, for all. All substances produced by nature can be recognized; all cells talk the same language as we all are from the same mother cell. Journal of Natural Remedies is devoted toward the understandings of all remedies from nature. Journal of Natural Remedies publishes original articles related to utilisation of any natural source for remedy including bioactive natural products. Studies related to the resources, chemistry (including analytical), biological activity, biotechnology and pharmacology (including toxicology) of archaea, bacteria, protistas, fungi, plants, animals, viruses and minerals fall within the journal’s scope.