"小儿肢端肥大症肢端肥大症伴有明显正常的 GH,这是一个独立的实体吗?

IF 6.1 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Lucio Vilar , Luciana Ansaneli Naves , Manoel Ricardo Alves Martins , Antônio Ribeiro-Oliveira Jr
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引用次数: 0

摘要

一小部分肢端肥大症患者的基础 GH 水平明显正常,尽管 IGF-1 水平升高,但 GH 水平仍可受到抑制,一些学者将这种模式称为微小肢端肥大症。这种模式是代表一个独特的实体,还是只是肢端肥大症早期阶段的一种表现,目前仍有争议。不过,这些患者有一些特殊的特征,如更可能是老年人和男性,大多患有微腺瘤或小的大腺瘤,IGF-1 和糖后 GH 水平较低。尽管如此,其临床症状和合并症的频率和严重程度与典型肢端肥大症患者相似。总之,微小肢端肥大症似乎是一种不同的临床实体,具有不同的生物学行为,其特点是 GH 输出较低。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
“Micromegaly”: Acromegaly with apparently normal GH, an entity on its own?

A small proportion of the patients with acromegaly present with apparently normal basal GH levels and suppressible GH levels despite increased IGF-1 levels, a pattern called micromegaly by some authors. Whether this pattern represents a distinct entity or is just an expression of acromegaly in its early stages is still a matter of debate. Nevertheless, these patients have some peculiar characteristics such as being more likely older and male, mostly harbour microadenomas or small macroadenomas, and have lower IGF-1 and postglucose GH levels. Even though, the frequency and severity of clinical signs and comorbidities are similar to those of patients with classic acromegaly. In conclusion, micromegaly seems to be a distinct clinical entity with a different biological behavior characterized by a low GH output.

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来源期刊
CiteScore
11.90
自引率
0.00%
发文量
77
审稿时长
6-12 weeks
期刊介绍: Best Practice & Research Clinical Endocrinology & Metabolism is a serial publication that integrates the latest original research findings into evidence-based review articles. These articles aim to address key clinical issues related to diagnosis, treatment, and patient management. Each issue adopts a problem-oriented approach, focusing on key questions and clearly outlining what is known while identifying areas for future research. Practical management strategies are described to facilitate application to individual patients. The series targets physicians in practice or training.
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