Hemidesmus indicus R. Br.的抗尿酸盐和利尿潜能

Q2 Pharmacology, Toxicology and Pharmaceutics
Saumya Das, Avijit Mazumder, Smriti Ojha, Deepika Pathak, Himanshu Singh, Pratibha Pandey, Rashmi Saxena Pal
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引用次数: 0

摘要

本研究调查了乙二醇和 COX-2 选择性抑制剂诱导的尿石症动物模型中肾结石形成的发展情况,以及利普希茨试验对 Wistar 大鼠的利尿潜能。在尿路结石模型中,塞来昔布能增加尿酶的排泄,但不影响草酸盐或柠檬酸盐的排泄。这项研究全面介绍了籼稻作为抗尿石症和利尿剂在动物模型中的民族植物学用途。将植物材料干燥、粉碎成干粉,用乙醇提取,并分析其中是否含有各种次生代谢物。实验数据表明,白花蛇舌草根提取物(HIEE)具有显著的抗尿路结石作用,不仅能防止肾结石的形成,还能减少晶体的成核、抑制晶体的生长、减少晶体的聚集以及晶体在肾小管内的滞留。补充 HIEE 可以防止肾结石的形成,组织学研究结果也证实了这一点。研究结果表明,HIEE 对实验诱导的尿路结石有效,对治疗后的动物也有强效利尿作用。因此,今后需要对药用植物进行研究,包括针对尿石症的体内机理和人体研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Anti Urolithiatic and Diuretic Potentiality of Hemidesmus indicus R. Br.
The present study investigated the development of kidney stone formation in animal models involving renal tubular stone formation by ethylene glycol and COX-2 selective inhibitor-induced urolithiasis along with the diuretic potentiality by Lipschitz teston Wistar rats. Hemidesmus indicus (H. indicus) R. Br. played a prominent role in various ancient traditional systems of medications and possessed various pharmacological applications. Since the last few decades, urolithiasis has been a major constraint in both livestock and human health. Celecoxib administration increased urinary enzyme excretion but did not affect oxalate or citrate excretion in a urolithiasis model. This research provides a comprehensive account of the ethnobotanical use of H. indicus as an antiurolithiatic and diuretic agent in animal models. The plant material was dried, pulverized into a dry powder, extracted with ethanol, and analyzed for the presence of various secondary metabolites. The anti-urolithic effect of ethanolic extract of H. indicus roots in albino rats was investigated using ethylene glycol (0.75%) and COX -2 selective inhibitor models The experimental data showed the significant effect of H. Indicus root extract (HIEE) as anti-urolithiasis by the prevention of kidney stone formation, also by decreasing crystal nucleation, growth inhibition, decreased aggregation, and crystal retention within the renal tubules. The effect of HIEE supplementation prevents the impairment of renal stone formation, which was also confirmed by the histological findings. HIEE also acts as a potent diuretic, which supports the study. The results indicated that HIEE was effective against experimentally induced urolithiasis, and it also acts as a potent diuretic in treated animals. So, it needs to perform future research on medicinal plants, including in vivo mechanistic and human studies for urolithiasis.
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来源期刊
Current Bioactive Compounds
Current Bioactive Compounds Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)
CiteScore
1.90
自引率
0.00%
发文量
112
期刊介绍: The journal aims to provide comprehensive review articles on new bioactive compounds with proven activities in various biological screenings and pharmacological models with a special emphasis on stereoeselective synthesis. The aim is to provide a valuable information source of bioactive compounds synthesized or isolated, which can be used for further development of pharmaceuticals by industry and academia. The journal should prove to be essential reading for pharmacologists, natural product chemists and medicinal chemists who wish to be kept informed and up-to-date with the most important developments on new bioactive compounds of natural or synthetic origin, including their stereoeselective synthesis.
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