Sarcopenia 与胸膜间皮瘤:现有知识

Muscles Pub Date : 2024-02-08 DOI:10.3390/muscles3010006
Nikolaos D. Karakousis, Konstantinos I. Gourgoulianis, N. Papanas, O. Kotsiou
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引用次数: 0

摘要

胸膜间皮瘤(PM)是一种预后不良的肿瘤。世界卫生组织的胸膜间皮瘤分类主要确定了胸膜间皮瘤的三大亚型,即上皮样型、双相型和肉瘤样型。肌肉疏松症是一个与肌肉质量和力量减少有关的医学问题。它是一个全球性的重大健康问题,因为它与住院、住院时间延长、残疾、发病率和死亡率增加以及医疗保健支出增加等不利影响有关。在这篇文献综述中,我们试图研究肌肉疏松症与 PM 之间即将发生的关联。根据目前的文献记录,慢性阻塞性肺病患者的肌肉流失与存活率较低和活动量较少有关。患有渐冻人症的受试者中,肌肉疏松症前期和营养不良的比例较高,而肌肉疏松症前期与活动水平较差有关,营养不良则与生活质量(QoL)较差有关。肿瘤体积和肌肉疏松症与接受手术治疗的 PM 受试者的长期死亡率有关,而这些受试者在术前和术后都存在肌肉疏松症。此外,与无肌肉疏松症的受试者相比,术后肌肉疏松症受试者的三年总生存率(OS)有所下降,而术前肌肉疏松症与术后不良预后率增加有重要关系。还需要更多的研究来验证这些说法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Sarcopenia and Pleural Mesothelioma: The Current Knowledge
Pleural mesothelioma (PM) is a tumor related to adverse prognosis. The PM WHO classification has mainly identified three major subtypes of PM which are epithelioid, biphasic, and sarcomatoid. Sarcopenia is a medical issue related to a reduction in muscle mass and strength. It represents a major health issue globally because it is related to adverse effects such as hospitalization, increased length of stay, disability, increased morbidity and mortality and augmented health care expenditures. In this literature review, we attempted to examine the upcoming association between sarcopenia and PM. As recorded by the current literature, muscle loss in PM subjects was related to poorer survival and lower levels of activity. Subjects with PM had increased rates of pre-sarcopenia and malnutrition, while pre-sarcopenia was related to worse activity levels, and malnutrition was related to worse quality of life (QoL). Both tumor volume and sarcopenia were related to long-term mortality in surgically treated PM subjects, while sarcopenia was present both pre-operatively and post-operatively in these subjects. In addition, post-operative sarcopenic subjects showed a decreased 3-year overall survival (OS) in comparison with those who did not have sarcopenia, while pre-operative sarcopenia was importantly related to an increased rate of post-operative adverse outcomes. More studies are needed to validate these claims.
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