全缝合半月板修复技术与半月板部分切除术治疗水平裂缝撕裂相比具有成本效益

Q3 Medicine
Seth L. Sherman M.D. , Neil Askew M.Sc. , Leo M. Nherera Ph.D. , Richard J. Searle Ph.D. , David C. Flanigan M.D.
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引用次数: 0

摘要

目的从美国支付方的角度,确定采用全缝合技术进行半月板修复术(MR)与半月板部分切除术(PM)治疗水平裂缝撕裂(HCT)的成本效益。方法从美国支付方的角度建立了一个状态转换模型和成本效用分析,以预测基线无骨关节炎、出现外侧或内侧 HCT 的 35 岁患者的治疗成本和质量调整生命年(QALYs)。研究采用了两种门诊成本计算视角,即非住院手术中心(ASC)和医院。状态转换模型有 7 种健康状态,其转换概率、成本和效用均来自现有文献。成本效益采用 100,000 美元/QALY 的支付意愿阈值进行评估,敏感性分析考虑了参数不确定性对模型结果的影响。MR 的失败率主要集中在全缝合技术上;但在另一种情况下,本研究考虑了各种 MR 技术和设备的有效性数据。结果 MR 在整个生命周期内对 PM 起主导作用,每位患者的 QALY 增加了 0.43,在医院环境下每位患者的成本降低了 12,227 美元(在 ASC 环境下降低了 12,570 美元)。当初治年龄在 30 岁至 60 岁之间时,采用全缝合技术的 MR 仍是最主要的治疗方法。敏感性分析表明,从 ASC 和医院的角度来看,MR 在第 1 年不具有成本效益,从第 2 年起具有成本效益,从第 6 年起可节省成本。概率敏感性分析发现,在基础病例分析的 10,000 次迭代中,有 99% 的迭代结果显示 MR 在整个生命周期内都具有成本效益。结论本研究发现,从支付方的角度来看,与 PM 相比,MR 是一种可为 HCT 患者节省成本的干预措施。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
An All-Suture–Based Technique for Meniscal Repair Is Cost-Effective in Comparison to Partial Meniscectomy for Horizontal Cleavage Tears

Purpose

To determine the cost-effectiveness of meniscal repair (MR) using an all-suture–based technique when compared to partial meniscectomy (PM) for horizontal cleavage tears (HCTs) from a payor’s perspective in the United States.

Methods

A state-transition model and cost-utility analysis were developed from a US payor’s perspective to project treatment costs and quality-adjusted life-years (QALYs) in a cohort of 35-year-old patients without osteoarthritis at baseline and presenting with either a lateral or medial HCT. Two outpatient costing perspectives were used, namely ambulatory surgical centers (ASCs) and hospitals. The state-transition model had 7 health states with transition probabilities, costs, and utilities obtained from the existing literature. Cost-effectiveness was assessed using a willingness-to-pay threshold of $100,000/QALY, and sensitivity analysis considered the effects of parameter uncertainty on model results. MR failure rates were focused on an all-suture–based technique; however, in a separate scenario, this study considered effectiveness data from various MR techniques and devices.

Results

MR dominated PM over a lifetime horizon, increasing QALYs by 0.43 per patient and decreasing the cost by $12,227 per patient within a hospital setting (and by $12,570 within an ASC). MR with an all-suture–based technique continued to be the dominant treatment when age at primary treatment was varied between 30 and 60 years. Sensitivity analysis showed that MR was not cost-effective in year 1, was cost-effective from year 2, and was cost-saving from year 6 onward from both ASC and hospital perspectives. Probabilistic sensitivity analysis found that MR was cost-effective over a lifetime horizon in 99% of 10,000 iterations on base-case analysis.

Conclusions

Using a lifetime horizon, this study found that from a payor’s perspective, MR is a cost-saving intervention when compared with PM in patients with an HCT.

Level of Evidence

Level III, economic analysis.

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来源期刊
CiteScore
2.70
自引率
0.00%
发文量
218
审稿时长
45 weeks
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