大肠杆菌和沙门氏菌的转录激活。

Q1 Medicine

EcoSal Plus Pub Date : 2024-12-12 Epub Date: 2024-02-12 DOI:10.1128/ecosalplus.esp-0039-2020

Stephen J W Busby, Douglas F Browning

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引用次数: 0

摘要

在大肠杆菌和沙门氏菌中，启动子特异性激活转录本启动是一种重要的调控手段。在这里，我们描述了不同的运作机制，重点是它们是如何进化来管理 "看家 "细菌转录机制的。一些机制涉及辅助细菌的 DNA 依赖性 RNA 聚合酶，或替换或重塑其一个亚基。其他机制则针对染色体 DNA、改善启动子功能或缓解抑制。我们将讨论不同的激活因子如何在启动子上协同工作，以及目前复杂的转录因子网络是如何演变而来的。

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Transcription activation in Escherichia coli and Salmonella.

Promoter-specific activation of transcript initiation provides an important regulatory device in Escherichia coli and Salmonella. Here, we describe the different mechanisms that operate, focusing on how they have evolved to manage the "housekeeping" bacterial transcription machinery. Some mechanisms involve assisting the bacterial DNA-dependent RNA polymerase or replacing or remodeling one of its subunits. Others are directed to chromosomal DNA, improving promoter function, or relieving repression. We discuss how different activators work together at promoters and how the present complex network of transcription factors evolved.

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来源期刊

EcoSal Plus Immunology and Microbiology-Microbiology

CiteScore

12.20

自引率

0.00%

发文量

期刊介绍： EcoSal Plus is the authoritative online review journal that publishes an ever-growing body of expert reviews covering virtually all aspects of E. coli, Salmonella, and other members of the family Enterobacteriaceae and their use as model microbes for biological explorations. This journal is intended primarily for the research community as a comprehensive and continuously updated archive of the entire corpus of knowledge about the enteric bacterial cell. Thoughtful reviews focus on physiology, metabolism, genetics, pathogenesis, ecology, genomics, systems biology, and history E. coli and its relatives. These provide the integrated background needed for most microbiology investigations and are essential reading for research scientists. Articles contain links to E. coli K12 genes on the EcoCyc database site and are available as downloadable PDF files. Images and tables are downloadable to PowerPoint files.