神经营养天然产品。

Q1 Medicine
Yoshiyasu Fukuyama, Miwa Kubo, Kenichi Harada
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引用次数: 0

摘要

神经营养素(NGF、BDNF、NT3、NT4)可以减少细胞死亡、诱导分化以及维持神经元的结构和功能,因此是治疗神经退行性疾病的理想药物。然而,神经营养素在临床试验中并不十分有效,这主要是因为它们是高分子量蛋白质,无法通过血脑屏障。因此,能刺激内源性神经营养素合成或增强神经营养作用的神经营养素模拟小分子可能成为神经营养素的有前途的替代品。小分子量天然产物在人类历史上一直被用于膳食功能食品或传统医药中,在开发针对神经退行性疾病(如阿尔茨海默病)的新治疗药物方面具有巨大潜力。本文介绍了多种具有神经营养特性的天然产物,如神经发生、神经元外生促进(神经元生成)和神经保护,并重点介绍了几种神经营养天然产物的化学和生物学特性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Neurotrophic Natural Products.

Neurotrophins (NGF, BDNF, NT3, NT4) can decrease cell death, induce differentiation, as well as sustain the structure and function of neurons, which make them promising therapeutic agents for the treatment of neurodegenerative disorders. However, neurotrophins have not been very effective in clinical trials mostly because they cannot pass through the blood-brain barrier owing to being high-molecular-weight proteins. Thus, neurotrophin-mimic small molecules, which stimulate the synthesis of endogenous neurotrophins or enhance neurotrophic actions, may serve as promising alternatives to neurotrophins. Small-molecular-weight natural products, which have been used in dietary functional foods or in traditional medicines over the course of human history, have a great potential for the development of new therapeutic agents against neurodegenerative diseases such as Alzheimer's disease. In this contribution, a variety of natural products possessing neurotrophic properties such as neurogenesis, neurite outgrowth promotion (neuritogenesis), and neuroprotection are described, and a focus is made on the chemistry and biology of several neurotrophic natural products.

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CiteScore
4.40
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