COVID-19 大流行期间甲醇中毒患者的脑内出血:病例报告和文献综述。

IF 2.8 4区 医学 Q2 TOXICOLOGY
Forensic Toxicology Pub Date : 2024-07-01 Epub Date: 2024-02-09 DOI:10.1007/s11419-023-00680-y
Hosein Safari, Reza Ajudani, Mohsen Savaie, Armin Jahangiri Babadi, Pooyan Alizadeh
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引用次数: 0

摘要

目的:本研究旨在探讨 COVID-19 大流行期间甲醇中毒的临床和影像学表现,并回顾现有的相关研究。甲醇中毒最常见的原因是掺有甲醇的白酒。甲醇的主要代谢产物甲酸会导致病理变化。症状通常在饮用后 6-24 小时内出现,包括视觉障碍、急性神经症状和胃肠道问题。在 COVID-19 大流行的最初一年,甲醇中毒病例显著增加:在本研究中,我们介绍了六名不同的甲醇中毒患者及其临床和影像学特征:在文献综述中,最常见的临床表现是意识丧失和昏迷,另一种是视力丧失。CT扫描结果显示,55%的甲醇中毒患者出现双侧副乳头坏死和出血:结论:甲醇中毒会导致双侧副中枢受累,脑出血患者的死亡率为 50%,因此需要对潜在的副中枢出血进行紧急毒理学分析。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Intracerebral hemorrhage in methanol toxicity patients during COVID-19 pandemic: case report and review of literature.

Intracerebral hemorrhage in methanol toxicity patients during COVID-19 pandemic: case report and review of literature.

Purpose: The aim of this study is to examine the clinical and imaging manifestations of methanol toxicity during the COVID-19 pandemic, as well as to review existing studies on this topic. The most common cause of methanol intoxication is methanol-adulterated liquor. The primary metabolite of methanol, formic acid, is responsible for pathological changes. Symptoms typically present within 6-24 h of consumption and can include visual disturbances, acute neurological symptoms, and gastrointestinal issues. During the initial year of the COVID-19 pandemic, methanol poisoning cases increased significantly.

Methods: In this study, We present six different patients with methanol intoxication and their clinical and imaging features.

Results: In the literature review, the most common clinical presentation was loss of consciousness and obtundation and the other was vision loss. CT scan findings showed bilateral putaminal necrosis and hemorrhage in 55% of methanol toxicity patients.

Conclusion: Methanol intoxication, causing bilateral putaminal involvement and a 50% mortality rate in intracerebral hemorrhage patients, warrants urgent toxicological analysis due to potential putaminal hemorrhage.

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来源期刊
Forensic Toxicology
Forensic Toxicology TOXICOLOGY-
CiteScore
5.80
自引率
9.10%
发文量
40
审稿时长
3 months
期刊介绍: The journal Forensic Toxicology provides an international forum for publication of studies on toxic substances, drugs of abuse, doping agents, chemical warfare agents, and their metabolisms and analyses, which are related to laws and ethics. It includes original articles, reviews, mini-reviews, short communications, and case reports. Although a major focus of the journal is on the development or improvement of analytical methods for the above-mentioned chemicals in human matrices, appropriate studies with animal experiments are also published. Forensic Toxicology is the official publication of the Japanese Association of Forensic Toxicology (JAFT) and is the continuation of the Japanese Journal of Forensic Toxicology (ISSN 0915-9606).
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