Hye-Won Jeong , Jae Hwan Kim , Sang-bin Han , Hye-Mee Kwon , In-Gu Jun , Jun-Gol Song , Gyu-Sam Hwang
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Propensity score matched (PSM) and inverse probability of treatment weighting (IPTW) analyses were performed to evaluate the association between preoperative NSBB use and postoperative AKI. Multiple logistic regression analyses were also used to identify the risk factors for AKI.</p></div><div><h3>Results</h3><p>The overall incidence of AKI was 1,721 (57.9%) cases. The NSBB group showed a higher incidence of AKI than the non-NSBB group (62.4% vs. 56.7%; <em>P</em> = 0.011). After PSM and IPTW analyses, no significant difference in the incidence of AKI was found between the two groups (Odds ratio, OR 1.13, 95% confidence interval, CI 0.93–1.37, <em>P</em> = 0.230, PSM analysis; OR 1.20, 95% CI 0.99–1.44, <em>P</em> = 0.059, IPTW analysis). In addition, preoperative NSBB use was not associated with AKI after multivariate logistic regression analysis (OR 1.16, 95% CI 0.96–1.40, <em>P</em> = 0.118).</p></div><div><h3>Conclusions</h3><p>Preoperative NSBB use was not associated with AKI after LDLT. 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The impact of nonselective beta-blockers (NSBBs) in patients with liver cirrhosis remains controversial. This study investigated the association between preoperative NSBB use and AKI after living donor LT (LDLT).</p></div><div><h3>Patients and Methods</h3><p>We evaluated 2,972 adult LDLT recipients between January 2012 and July 2022. The patients were divided into two groups based on the preoperative NSBB use. Propensity score matched (PSM) and inverse probability of treatment weighting (IPTW) analyses were performed to evaluate the association between preoperative NSBB use and postoperative AKI. Multiple logistic regression analyses were also used to identify the risk factors for AKI.</p></div><div><h3>Results</h3><p>The overall incidence of AKI was 1,721 (57.9%) cases. The NSBB group showed a higher incidence of AKI than the non-NSBB group (62.4% vs. 56.7%; <em>P</em> = 0.011). 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引用次数: 0
摘要
引言和目的：急性肾损伤（AKI）很普遍，对肝移植（LT）术后的预后有不利影响。非选择性β受体阻滞剂（NSBB）对肝硬化患者的影响仍存在争议。本研究调查了活体肝移植（LDLT）术前使用非选择性β受体阻滞剂与AKI之间的关系：我们对 2012 年 1 月至 2022 年 7 月间的 2,972 名成年 LDLT 受者进行了评估。根据术前使用 NSBB 的情况将患者分为两组。进行倾向评分匹配（PSM）和逆治疗概率加权（IPTW）分析，以评估术前使用 NSBB 与术后 AKI 之间的关联。此外，还采用多元逻辑回归分析来确定AKI的风险因素：结果：AKI的总发生率为1,721例（57.9%）。NSBB组的AKI发生率高于非NSBB组（62.4% vs. 56.7%; P = 0.011）。经过 PSM 和 IPTW 分析后，两组的 AKI 发生率无明显差异（Odds ratio，OR 1.13，95% 置信区间，CI 0.93-1.37，P = 0.230，PSM 分析；OR 1.20，95% 置信区间，CI 0.99-1.44，P = 0.059，IPTW 分析）。此外，经过多变量逻辑回归分析，术前使用 NSBB 与 AKI 无关（OR 1.16，95 % CI 0.96-1.40，P = 0.118）：结论：术前使用NSBB与LDLT术后AKI无关。结论：术前使用 NSBB 与 LDLT 后的 AKI 无关。
Impact of preoperative nonselective beta-blocker use on acute kidney injury after living donor liver transplantation: Propensity score analysis
Introduction and Objectives
Acute kidney injury (AKI) is prevalent and has deleterious effects on postoperative outcomes following liver transplantation (LT). The impact of nonselective beta-blockers (NSBBs) in patients with liver cirrhosis remains controversial. This study investigated the association between preoperative NSBB use and AKI after living donor LT (LDLT).
Patients and Methods
We evaluated 2,972 adult LDLT recipients between January 2012 and July 2022. The patients were divided into two groups based on the preoperative NSBB use. Propensity score matched (PSM) and inverse probability of treatment weighting (IPTW) analyses were performed to evaluate the association between preoperative NSBB use and postoperative AKI. Multiple logistic regression analyses were also used to identify the risk factors for AKI.
Results
The overall incidence of AKI was 1,721 (57.9%) cases. The NSBB group showed a higher incidence of AKI than the non-NSBB group (62.4% vs. 56.7%; P = 0.011). After PSM and IPTW analyses, no significant difference in the incidence of AKI was found between the two groups (Odds ratio, OR 1.13, 95% confidence interval, CI 0.93–1.37, P = 0.230, PSM analysis; OR 1.20, 95% CI 0.99–1.44, P = 0.059, IPTW analysis). In addition, preoperative NSBB use was not associated with AKI after multivariate logistic regression analysis (OR 1.16, 95% CI 0.96–1.40, P = 0.118).
Conclusions
Preoperative NSBB use was not associated with AKI after LDLT. Further studies are needed to validate our results.
期刊介绍：
Annals of Hepatology publishes original research on the biology and diseases of the liver in both humans and experimental models. Contributions may be submitted as regular articles. The journal also publishes concise reviews of both basic and clinical topics.
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