受体酪氨酸激酶样孤儿受体 1 如何在慢性淋巴细胞白血病中与其伙伴相遇

IF 3.3 4区 医学 Q2 HEMATOLOGY
Nayla Mouawad, Edoardo Ruggeri, Guido Capasso, Leonardo Martinello, Andrea Visentin, Federica Frezzato, Livio Trentin
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引用次数: 0

摘要

慢性淋巴细胞白血病(CLL)是西方社会最常见的白血病,具有临床和分子异质性。尽管靶向疗法取得了成功,但获得性耐药性仍然是复发和难治性 CLL 面临的挑战,这是由于靶点突变或其他生存途径上调导致疾病进展的结果。对能触发此类通路的蛋白质进行研究,可能会确定新的疗法,如受体酪氨酸激酶样孤儿受体1(ROR1),从而成功治疗CLL。ROR1 是 Wnt5a 的信号受体,在胚胎发育过程中发挥着重要作用。ROR1 在 CLL 细胞和几种肿瘤中的异常表达参与了细胞的增殖、存活、迁移和耐药性。在临床前和临床研究中,出现了针对 ROR1 的抗体免疫疗法和小分子化合物。人们一直在努力寻找具有预测价值的新预后标志物,以完善和提高对 CLL 的检测和管理。ROR1 可被视为 CLL 诊断、预后和治疗的一个有吸引力的靶点。它可以单独使用和/或与目前已批准的药物联合使用,具有临床疗效。在这篇综述中,我们总结了以 ROR1 为靶点进行 CLL 诊断、预后和治疗的科研成果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

How receptor tyrosine kinase-like orphan receptor 1 meets its partners in chronic lymphocytic leukemia

How receptor tyrosine kinase-like orphan receptor 1 meets its partners in chronic lymphocytic leukemia

Chronic lymphocytic leukemia (CLL) is the most common leukemia in western societies, recognized by clinical and molecular heterogeneity. Despite the success of targeted therapies, acquired resistance remains a challenge for relapsed and refractory CLL, as a consequence of mutations in the target or the upregulation of other survival pathways leading to the progression of the disease. Research on proteins that can trigger such pathways may define novel therapies for a successful outcome in CLL such as the receptor tyrosine kinase-like orphan receptor 1 (ROR1). ROR1 is a signaling receptor for Wnt5a, with an important role during embryogenesis. The aberrant expression on CLL cells and several types of tumors, is involved in cell proliferation, survival, migration as well as drug resistance. Antibody-based immunotherapies and small-molecule compounds emerged to target ROR1 in preclinical and clinical studies. Efforts have been made to identify new prognostic markers having predictive value to refine and increase the detection and management of CLL. ROR1 can be considered as an attractive target for CLL diagnosis, prognosis, and treatment. It can be clinically effective alone and/or in combination with current approved agents. In this review, we summarize the scientific achievements in targeting ROR1 for CLL diagnosis, prognosis, and treatment.

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来源期刊
Hematological Oncology
Hematological Oncology 医学-血液学
CiteScore
4.20
自引率
6.10%
发文量
147
审稿时长
>12 weeks
期刊介绍: Hematological Oncology considers for publication articles dealing with experimental and clinical aspects of neoplastic diseases of the hemopoietic and lymphoid systems and relevant related matters. Translational studies applying basic science to clinical issues are particularly welcomed. Manuscripts dealing with the following areas are encouraged: -Clinical practice and management of hematological neoplasia, including: acute and chronic leukemias, malignant lymphomas, myeloproliferative disorders -Diagnostic investigations, including imaging and laboratory assays -Epidemiology, pathology and pathobiology of hematological neoplasia of hematological diseases -Therapeutic issues including Phase 1, 2 or 3 trials as well as allogeneic and autologous stem cell transplantation studies -Aspects of the cell biology, molecular biology, molecular genetics and cytogenetics of normal or diseased hematopoeisis and lymphopoiesis, including stem cells and cytokines and other regulatory systems. Concise, topical review material is welcomed, especially if it makes new concepts and ideas accessible to a wider community. Proposals for review material may be discussed with the Editor-in-Chief. Collections of case material and case reports will be considered only if they have broader scientific or clinical relevance.
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