无创胎儿血型抗原基因分型。

IF 2.3 3区医学 Q2 HEMATOLOGY

Blood Transfusion Pub Date : 2025-03-01 Epub Date: 2024-01-29 DOI:10.2450/BloodTransfus.712

Frederik B Clausen, C Ellen van der Schoot

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引用次数: 0

摘要

无创胎儿血型抗原基因分型可作为一种诊断工具，用于预测已接受免疫的孕妇的胎儿和新生儿患溶血性疾病的风险。此外，胎儿 RHD 基因分型还可用作产前筛查，以指导未接受免疫的 RhD 阴性孕妇有针对性地使用免疫球蛋白进行预防。这些无创检测基于对从母体血浆中提取的无细胞 DNA 的检测，具有很高的准确性。因此，无创胎儿血型抗原基因分型已成为输血医学的标准疗法。

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Noninvasive fetal blood group antigen genotyping.

Noninvasive fetal blood group antigen genotyping serves as a diagnostic tool to predict the risk of hemolytic disease of the fetus and newborn in pregnancies of immunized women. In addition, fetal RHD genotyping is used as an antenatal screening to guide targeted use of immunoglobulin prophylaxis in non-immunized RhD negative, pregnant women. Based on testing of cell-free DNA extracted from maternal plasma, these noninvasive assays demonstrate high performance accuracies. Consequently, noninvasive fetal blood group antigen genotyping has become standard care in transfusion medicine.

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来源期刊

Blood Transfusion HEMATOLOGY-

CiteScore

6.10

自引率

2.70%

发文量

审稿时长

2 months

期刊介绍： Blood Transfusion welcomes international submissions of Original Articles, Review Articles, Case Reports and Letters on all the fields related to Transfusion Medicine.