利用长视场扫描对前列腺癌患者进行单独延迟[68 Ga]Ga-PSMA-11 PET/CT 的图像质量和可行性。

IF 3.1 3区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Xiaofeng Yu, Lian Xu, Gang Huang, Jianjun Liu, Ruohua Chen, Yumei Chen
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引用次数: 0

摘要

背景:先前的研究表明,与早期[68 Ga]Ga-PSMA PET/CT相比,延迟[68 Ga]Ga-PSMA PET/CT成像可提高前列腺癌患者的病灶检测率。然而,由于标准 PET/CT 扫描仪获得的光子数量不足,延迟[68 Ga]Ga-PSMA PET/CT 的单独使用受到了限制。可以考虑将早期和延迟[68 Ga]Ga-PSMA 标准 PET/CT 结合使用,但将其纳入高要求的临床环境具有挑战性。与标准 PET/CT 相比,长视场 (LFOV) PET/CT 扫描仪具有更高的灵敏度。然而,单独延迟[68 Ga]Ga-PSMA LFOV PET/CT 成像的图像质量是否足以满足临床诊断要求仍是未知数。因此,本研究的目的是评估延迟[68 Ga]Ga-PSMA LFOV PET/CT的图像质量,并研究在前列腺癌患者中单独使用延迟[68 Ga]Ga-PSMA LFOV PET/CT成像的可行性:研究样本包括在2020年12月至2021年7月期间接受[68 Ga]Ga-PSMA-11 LFOV PET/CT扫描的56例前列腺癌患者。所有患者均在注射[68 Ga]Ga-PSMA-11 后 1 小时接受了早期 LFOV PET/CT 扫描,并在注射后 3 小时接受了延迟 LFOV PET/CT 扫描。结果显示,延迟[68 Ga]Ga-PSMA-11 LFOV PET/CT成像的图像质量和诊断效率均优于[68 Ga]Ga-PSMA-11 LFOV PET/CT成像:结果表明,延迟[68 Ga]Ga-PSMA-11 LFOV PET/CT成像质量令人满意,符合临床诊断基准。与早期成像相比,延迟[68 Ga]Ga-PSMA-11 LFOV PET/CT显示病变SUVmax值升高(11.0 [2.3-193.6] vs. 7.0 [2.0-124.3], P 68 Ga]Ga-PSMA-11 LFOV PET/CT与早期成像相比检测出14例患者(25%)的补充病变,导致疾病分期和管理计划的修改:总之,研究结果表明,延迟[68 Ga]Ga-PSMA-11 LFOV PET/CT的图像质量令人满意,可满足临床诊断的先决条件。与[68 Ga]Ga-PSMA-11标准PET/CT相比,[68 Ga]Ga-PSMA-11 LFOV PET/CT需要同时进行早期和延迟成像,而在前列腺癌中使用单独的延迟[68 Ga]Ga-PSMA-11 LFOV PET/CT成像简化了检查方案,提高了患者的依从性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The image quality and feasibility of solitary delayed [68 Ga]Ga-PSMA-11 PET/CT using long field-of-view scanning in patients with prostate cancer.

Background: Previous studies have demonstrated that delayed [68 Ga]Ga-PSMA PET/CT imaging improves lesion detection compared to early [68 Ga]Ga-PSMA PET/CT in patients with prostate cancer. However, the sole use of delayed [68 Ga]Ga-PSMA PET/CT has been limited due to the insufficient number of photons obtained with standard PET/CT scanners. The combination of early and delayed [68 Ga]Ga-PSMA standard PET/CT may be considered, and it is challenging to incorporate into a high-demand clinical setting. Long field-of-view (LFOV) PET/CT scanners have higher sensitivity compared to standard PET/CT. However, it remains unknown whether the image quality of solitary delayed [68 Ga]Ga-PSMA LFOV PET/CT imaging is adequate to satisfy clinical diagnostic requirements. Therefore, the purpose of this study was to evaluate the image quality of delayed [68 Ga]Ga-PSMA LFOV PET/CT and examine the feasibility of utilizing delayed [68 Ga]Ga-PSMA LFOV PET/CT imaging alone in patients with prostate cancer.

Methods: The study sample consisted of 56 prostate cancer patients who underwent [68 Ga]Ga-PSMA-11 LFOV PET/CT scanning between December 2020 and July 2021. All patients were subjected to early LFOV PET/CT imaging at 1-h post-injection as well as delayed LFOV PET/CT imaging at 3-h post-injection using [68 Ga]Ga-PSMA-11. The image quality and diagnostic efficiency of solitary delayed [68 Ga]Ga-PSMA-11 LFOV PET/CT imaging was analyzed.

Results: The results showed that delayed [68 Ga]Ga-PSMA-11 LFOV PET/CT yielded satisfactory image quality that fulfilled clinical diagnostic benchmarks. Compared to early imaging, delayed [68 Ga]Ga-PSMA-11 LFOV PET/CT demonstrated heightened lesion SUVmax values (11.0 [2.3-193.6] vs. 7.0 [2.0-124.3], P < 0.001) and superior tumor-to-background ratios (3.3 [0.5-62.2] vs. 1.7 [0.3-30.7], P < 0.001). Additionally, delayed [68 Ga]Ga-PSMA-11 LFOV PET/CT detected supplementary lesions in 14 patients (25%) compared to early imaging, resulting in modifications to disease staging and management plans.

Conclusions: In summary, the findings indicate that the image quality of delayed [68 Ga]Ga-PSMA-11 LFOV PET/CT is satisfactory for meeting clinical diagnostic prerequisites. The use of solitary delayed [68 Ga]Ga-PSMA-11 LFOV PET/CT imaging in prostate cancer simplifies the examination protocol and improves patient compliance, compared to [68 Ga]Ga-PSMA-11 standard PET/CT which necessitates both early and delayed imaging.

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来源期刊
EJNMMI Research
EJNMMI Research RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING&nb-
CiteScore
5.90
自引率
3.10%
发文量
72
审稿时长
13 weeks
期刊介绍: EJNMMI Research publishes new basic, translational and clinical research in the field of nuclear medicine and molecular imaging. Regular features include original research articles, rapid communication of preliminary data on innovative research, interesting case reports, editorials, and letters to the editor. Educational articles on basic sciences, fundamental aspects and controversy related to pre-clinical and clinical research or ethical aspects of research are also welcome. Timely reviews provide updates on current applications, issues in imaging research and translational aspects of nuclear medicine and molecular imaging technologies. The main emphasis is placed on the development of targeted imaging with radiopharmaceuticals within the broader context of molecular probes to enhance understanding and characterisation of the complex biological processes underlying disease and to develop, test and guide new treatment modalities, including radionuclide therapy.
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