呼吸组学检测心血管疾病:妄想还是稀释代谢组特征?

IF 2.4 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Basheer Marzoog
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引用次数: 0

摘要

挥发性有机化合物(VOCs)可根据其来源细分为外源性和内源性两类。分析内源性挥发性有机化合物可为维持内脏器官的平衡提供见解。尽管目前的研究还在不断发展和深入,但研究表明,缺血性心脏病患者的心血管代谢改变与通过呼出气体分析检测到的乙烷和异戊二烯水平升高之间存在联系。相反,慢性心力衰竭患者呼出的气体中丙酮和戊烷含量升高。这些物质来源于心脏组织的紊乱,包括细胞和亚细胞的调节。根据推测,呼出气体分析中的乙烷含量可以显示缺血性心脏病的严重程度,进而显示未来 10 年因心血管疾病(CVD)死亡的风险。实时直接质谱法是评估呼气分析中挥发性有机化合物的首选方法。这种分析方法的准确性取决于多个因素,包括相关呼气成分的选择、呼气收集容器的类型(如果使用)以及预浓缩技术。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Breathomics Detect the Cardiovascular Disease: Delusion or Dilution of the Metabolomic Signature.

Volatile organic compounds (VOCs) can be subdivided into exogenous and endogenous categories based on their origin. Analyzing the endogenous VOCs can provide insights into maintaining the internal organs' homeostasis. Despite the ongoing development and the current understanding, studies have suggested a link between cardiovascular metabolic alterations in patients with ischemic heart disease and elevated levels of ethane and isoprene detectable through exhaled breath analysis. Conversely, patients with chronic heart failure exhibit elevated acetone and pentane in their exhaled air. These substances originate from disturbances in the heart tissue, including cellular and subcellular modulations. Hypothetically, ethane levels in the exhaled breath analysis can demonstrate the severity of ischemic heart disease and, consequently, the risk of death in the next 10 years due to cardiovascular disease (CVD). Real-time direct mass spectrometry is the preferred method for assessing VOCs in exhaled breath analysis. The accuracy of this analysis depends on several factors, including the selection of the relevant breath fraction, the type of breath collection container (if used), and the pre-concentration technique.

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来源期刊
Current Cardiology Reviews
Current Cardiology Reviews CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
3.70
自引率
10.50%
发文量
117
期刊介绍: Current Cardiology Reviews publishes frontier reviews of high quality on all the latest advances on the practical and clinical approach to the diagnosis and treatment of cardiovascular disease. All relevant areas are covered by the journal including arrhythmia, congestive heart failure, cardiomyopathy, congenital heart disease, drugs, methodology, pacing, and preventive cardiology. The journal is essential reading for all researchers and clinicians in cardiology.
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