综合分析揭示肺腺癌 DNA 甲基化调节因子的预后和免疫特性

IF 4.7 2区医学 Q1 RESPIRATORY SYSTEM

Respiratory Research Pub Date : 2024-02-05 DOI:10.1186/s12931-024-02695-4

Jing Huang, Chujian Huang, Can Huang, Zichang Xiang, Yao Ni, Jian Zeng, Songhua Cai

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引用次数: 0

摘要

DNA甲基化调节因子（DMRs）在DNA甲基化中起着关键作用，从而介导肿瘤的发生、转移和免疫调节。然而，在肺腺癌（LUAD）中，DMRs对临床结果和免疫治疗反应的影响仍未得到探讨。本研究利用了八个肺腺癌队列和一个肺癌免疫治疗队列。我们利用单变量和多变量 COX 回归分析构建了 DNA 甲基化调控因子相关特征（DMRRS）。DMRRS定义的低风险组与良好的预后、肿瘤抑制性微环境、对多种靶向治疗药物更敏感以及更好的免疫反应优先相关。随后，免疫治疗反应的预后价值和预测潜力也得到了验证。总之，我们的研究结果发现，DMRRS与肿瘤免疫微环境密切相关，能有效预测LUAD患者的临床预后和免疫反应。

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Comprehensive analysis reveals the prognostic and immunogenic characteristics of DNA methylation regulators in lung adenocarcinoma

DNA methylation regulators (DMRs) play a key role in DNA methylation, thus mediating tumor occurrence, metastasis, and immunomodulation. However, the effects of DMRs on clinical outcomes and immunotherapy response remain unexplored in lung adenocarcinoma (LUAD). In this study, eight LUAD cohorts and one immunotherapeutic cohort of lung cancer were utilized. We constructed a DNA methylation regulators-related signature (DMRRS) using univariate and multivariate COX regression analysis. The DMRRS-defined low-risk group was preferentially associated with favorable prognosis, tumor-inhibiting microenvironment, more sensitivity to several targeted therapy drugs, and better immune response. Afterward, the prognostic value and predictive potential in immunotherapy response were validated. Collectively, our findings uncovered that the DMRRS was closely associated with the tumor immune microenvironment and could effectively predict the clinical outcome and immune response of LUAD patients.

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来源期刊

Respiratory Research 医学-呼吸系统

自引率

1.70%

发文量

314

期刊介绍： Respiratory Research publishes high-quality clinical and basic research, review and commentary articles on all aspects of respiratory medicine and related diseases. As the leading fully open access journal in the field, Respiratory Research provides an essential resource for pulmonologists, allergists, immunologists and other physicians, researchers, healthcare workers and medical students with worldwide dissemination of articles resulting in high visibility and generating international discussion. Topics of specific interest include asthma, chronic obstructive pulmonary disease, cystic fibrosis, genetics, infectious diseases, interstitial lung diseases, lung development, lung tumors, occupational and environmental factors, pulmonary circulation, pulmonary pharmacology and therapeutics, respiratory immunology, respiratory physiology, and sleep-related respiratory problems.