二甲双胍的抗炎作用：分子靶点。

IF 1.3 4区生物学 Q4 CELL BIOLOGY

Genes to Cells Pub Date : 2024-02-04 DOI:10.1111/gtc.13098

Natsumi Sakata

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引用次数: 0

摘要

二甲双胍是一种抗糖尿病药物。二甲双胍主要抑制肝脏中的葡萄糖生成，降低血糖。除了抗糖尿病作用外，许多研究还发现二甲双胍具有抗炎作用。有研究认为二甲双胍抗炎作用的靶点是多种分子。然而，结论并不明确。二甲双胍与多种分子有关，而抗炎作用的主要靶点的确定有助于人们了解炎症和二甲双胍。在这篇文章中，我将讨论所提出的每个分子、相关机制及其与各种疾病的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

The anti-inflammatory effect of metformin: The molecular targets

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The anti-inflammatory effect of metformin: The molecular targets

Metformin is an anti-diabetic drug. Metformin mainly inhibits gluconeogenesis in the liver and reduces blood sugar. In addition to the anti-diabetic effects, many studies have revealed that metformin has anti-inflammatory effects. Various molecules were suggested to be the target of the metformin's anti-inflammatory effects. However, the conclusion is not clear. Metformin is related to a number of molecules and the identification of the main target in anti-inflammatory effects leads to the understanding of inflammation and metformin. In this article, I discuss each suggested molecule, involved mechanisms, and their relationship with various diseases.

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来源期刊

Genes to Cells 生物-细胞生物学

CiteScore

3.40

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： Genes to Cells provides an international forum for the publication of papers describing important aspects of molecular and cellular biology. The journal aims to present papers that provide conceptual advance in the relevant field. Particular emphasis will be placed on work aimed at understanding the basic mechanisms underlying biological events.