胰岛素抵抗、非酒精性脂肪肝和 2 型糖尿病:临床与实验视角

IF 6.8 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Diabetes & Metabolism Journal Pub Date : 2024-05-01 Epub Date: 2024-02-02 DOI:10.4093/dmj.2023.0350
Inha Jung, Dae-Jeong Koo, Won-Young Lee
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引用次数: 0

摘要

人们普遍认为,胰岛素抵抗(IR)和胰岛素分泌能力下降是 2 型糖尿病(T2DM)的基本发病机制。除遗传因素外,肥胖引起的持续性全身炎症和相关的脂毒性威胁也增加了罹患 T2DM 的风险。特别是,肥胖是导致红外的主要原因,根据最近的研究,患有 T2DM 的受试者的体重指数(BMI)高于正常受试者。在过去的三十年中,T2DM 和 IR 的发病率随着 BMI 的增加而增加。根据最近的研究,与 20 世纪 90 年代相比,IR 的稳态模型评估有所增加。韩国肥胖症发病率的上升导致了红外、非酒精性脂肪肝和 T2DM 的发展,因此切断这一恶性循环非常重要。20 多年来,我和我的同事们通过临床和实验研究,对这一主题的致病机制进行了调查。在此,我想对我们的一些研究进行总结,并对获得著名的 2023 年水原奖深表感谢。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Insulin Resistance, Non-Alcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus: Clinical and Experimental Perspective.

It has been generally accepted that insulin resistance (IR) and reduced insulin secretory capacity are the basic pathogenesis of type 2 diabetes mellitus (T2DM). In addition to genetic factors, the persistence of systemic inflammation caused by obesity and the associated threat of lipotoxicity increase the risk of T2DM. In particular, the main cause of IR is obesity and subjects with T2DM have a higher body mass index (BMI) than normal subjects according to recent studies. The prevalence of T2DM with IR has increased with increasing BMI during the past three decades. According to recent studies, homeostatic model assessment of IR was increased compared to that of the 1990s. Rising prevalence of obesity in Korea have contributed to the development of IR, non-alcoholic fatty liver disease and T2DM and cutting this vicious cycle is important. My colleagues and I have investigated this pathogenic mechanism on this theme through clinical and experimental studies over 20 years and herein, I would like to summarize some of our studies with deep gratitude for receiving the prestigious 2023 Sulwon Award.

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来源期刊
Diabetes & Metabolism Journal
Diabetes & Metabolism Journal Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
10.40
自引率
6.80%
发文量
92
审稿时长
52 weeks
期刊介绍: The aims of the Diabetes & Metabolism Journal are to contribute to the cure of and education about diabetes mellitus, and the advancement of diabetology through the sharing of scientific information on the latest developments in diabetology among members of the Korean Diabetes Association and other international societies. The Journal publishes articles on basic and clinical studies, focusing on areas such as metabolism, epidemiology, pathogenesis, complications, and treatments relevant to diabetes mellitus. It also publishes articles covering obesity and cardiovascular disease. Articles on translational research and timely issues including ubiquitous care or new technology in the management of diabetes and metabolic disorders are welcome. In addition, genome research, meta-analysis, and randomized controlled studies are welcome for publication. The editorial board invites articles from international research or clinical study groups. Publication is determined by the editors and peer reviewers, who are experts in their specific fields of diabetology.
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