压力生物学:健康与疾病的复杂性和多变性。

IF 3.3 3区 生物学 Q3 CELL BIOLOGY
Matthias P. Mayer , Laura Blair , Gregory L. Blatch , Thiago J. Borges , Ahmed Chadli , Gabriela Chiosis , Aurélie de Thonel , Albena Dinkova-Kostova , Heath Ecroyd , Adrienne L. Edkins , Takanori Eguchi , Monika Fleshner , Kevin P. Foley , Sotirios Fragkostefanakis , Jason Gestwicki , Pierre Goloubinoff , Jennifer A. Heritz , Christine M. Heske , Jonathan D. Hibshman , Jenny Joutsen , Tawanda Zininga
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引用次数: 0

摘要

在不断变化的环境条件或发育过程中保持和调节细胞的平衡,对于单细胞和多细胞生物都至关重要。为了抵消细胞平衡失调,转录程序发生了演变,被称为热休克反应(HSR)、未折叠蛋白反应(UPR)和综合应激反应(ISR)。这些转录程序下调了大多数基因的表达,但增加了热休克基因的表达,包括编码分子伴侣和蛋白酶的基因,这些蛋白参与修复应激引起的对大分子和细胞结构的损伤。费鲁齐奥-里托萨(Ferruccio Ritossa)发现热休克反应 61 年后,应激生物学的许多方面仍然是个谜。2023 年 10 月 28 日至 31 日在美国弗吉尼亚州亚历山大老城举行的第 12 届热休克蛋白在生物学、医学和环境中的应用国际研讨会上,报告了人们在理解应激反应和分子伴侣方面取得的最新进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Stress biology: Complexity and multifariousness in health and disease

Preserving and regulating cellular homeostasis in the light of changing environmental conditions or developmental processes is of pivotal importance for single cellular and multicellular organisms alike. To counteract an imbalance in cellular homeostasis transcriptional programs evolved, called the heat shock response, unfolded protein response, and integrated stress response, that act cell-autonomously in most cells but in multicellular organisms are subjected to cell-nonautonomous regulation. These transcriptional programs downregulate the expression of most genes but increase the expression of heat shock genes, including genes encoding molecular chaperones and proteases, proteins involved in the repair of stress-induced damage to macromolecules and cellular structures. Sixty-one years after the discovery of the heat shock response by Ferruccio Ritossa, many aspects of stress biology are still enigmatic. Recent progress in the understanding of stress responses and molecular chaperones was reported at the 12th International Symposium on Heat Shock Proteins in Biology, Medicine and the Environment in the Old Town Alexandria, VA, USA from 28th to 31st of October 2023.

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来源期刊
Cell Stress & Chaperones
Cell Stress & Chaperones 生物-细胞生物学
CiteScore
7.60
自引率
2.60%
发文量
59
审稿时长
6-12 weeks
期刊介绍: Cell Stress and Chaperones is an integrative journal that bridges the gap between laboratory model systems and natural populations. The journal captures the eclectic spirit of the cellular stress response field in a single, concentrated source of current information. Major emphasis is placed on the effects of climate change on individual species in the natural environment and their capacity to adapt. This emphasis expands our focus on stress biology and medicine by linking climate change effects to research on cellular stress responses of animals, micro-organisms and plants.
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