利用单轴拉伸试验研究兔虹膜的粘弹性、各向异性和机械性能的位置依赖性。

IF 0.8 4区 医学 Q4 BIOPHYSICS
Tan Li, Xiao Qin, Zhicheng Liu, Haixia Zhang, Lin Li
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引用次数: 0

摘要

目的:虹膜机械性能异常被认为是瞳孔阻滞和闭角型青光眼的重要原因。本研究采用单轴拉伸试验研究了兔虹膜的粘弹性、各向异性和机械性能的位置依赖性:方法:分别沿三个方向(内圆周方向(ICD)、外圆周方向(OCD)和径向方向(RD))取虹膜条。对虹膜条进行准静态拉伸试验和应力松弛试验。然后,用三阶奥格登模型拟合应力拉伸数据;用三阶普罗尼序列模型拟合应力松弛数据。通过比较不同方向和位置虹膜条的切线模量和松弛极限,探讨了兔虹膜的粘弹性、各向异性和力学性能的位置依赖性:沿 ICD、OCD 和 RD 拉伸 1.05 时虹膜的切线模量分别为 3.2 ± 1.4 kPa、4.2 ± 2.6 kPa 和 1.5 ± 0.8 kPa。结果发现,ICD 和 OCD 的虹膜条带具有几乎相同的应力松弛行为,且松弛速度均慢于 RD 的虹膜条带:结论:虹膜的机械特性具有典型的非线性、粘弹性、各向异性和位置依赖性。圆周方向虹膜带的应力增长率明显低于 RD,应力松弛率明显高于 RD。也就是说,RD中的虹膜更容易变形,而RD变形后的应力保持能力较弱,这与体内RD更容易发生虹膜爆裂的事实一致。本研究的结果还有助于我们建立更精确的有限元模型来模拟房水流场,并找到瞳孔阻滞的关键因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The viscoelasticity, anisotropy and location-dependence of mechanical properties of rabbit iris investigated using uniaxial tensile tests.

Purpose: Abnormal iris mechanical properties have been considered to be an important cause of pupillary-block and angle-closure glaucoma. In this research, viscoelasticity, anisotropy and location-dependence of mechanical properties of rabbit iris were investigated using uniaxial tensile test.

Methods: Iris strips were taken along three directions: inner-circumferential direction (ICD), outer-circumferential direction (OCD) and radial direction (RD), respectively. Quasi-static tensile tests and stress-relaxation tests were applied on the iris strips. Then, the stress-stretch data was fitted with third order Ogden model; the stress-relaxation data was fitted with the third order Prony series model. Through comparing the tangent modulus and relaxation limit of the strips from different directions and locations, the viscoelasticity, anisotropy and location-dependence of mechanical properties of rabbit iris were explored.

Results: The tangent moduli of iris at the stretch of 1.05 along ICD, OCD, and RD were 3.2 ± 1.4 kPa, 4.2 ± 2.6 kPa, 1.5 ± 0.8 kPa, respectively. Iris strips in ICD and OCD were found to have almost the same stress-relaxation behavior, and both relaxed slower than iris strips in RD.

Conclusions: The mechanical properties of the iris were typically nonlinear, viscoelastic, anisotropic and location-dependent. The stress growth rate of the circumferential direction iris strip is significantly lower than that of RD and the stress-relaxation rate is significantly higher than that of the RD. That is, the iris is more prone to deformation in RD and the stress-retention ability after deformation in RD is weak, which is consistent with the fact that the iris bombe more likely happens in RD in vivo. The results of this study may also help us to establish a more accurate finite element model to simulate the flow field of humor aqueous and find the key factor of pupillary-block.

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来源期刊
Acta of bioengineering and biomechanics
Acta of bioengineering and biomechanics BIOPHYSICS-ENGINEERING, BIOMEDICAL
CiteScore
2.10
自引率
10.00%
发文量
0
期刊介绍: Acta of Bioengineering and Biomechanics is a platform allowing presentation of investigations results, exchange of ideas and experiences among researchers with technical and medical background. Papers published in Acta of Bioengineering and Biomechanics may cover a wide range of topics in biomechanics, including, but not limited to: Tissue Biomechanics, Orthopedic Biomechanics, Biomaterials, Sport Biomechanics.
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