Kathleen Klaper , Hana Tlapák , Regina Selb , Klaus Jansen , Dagmar Heuer
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引用次数: 0
摘要
淋病奈瑟菌感染人数是全球三大性传播感染（STI）之一。此外，淋病奈瑟菌抗菌药耐药性（AMR）的出现和传播也是一个重要的公共卫生问题。整合基因组、表型和流行病学数据来监测淋病奈瑟菌，有助于我们了解淋病奈瑟菌中 AMR 的出现和传播情况，并为治疗指南和干预策略提供依据。因此，德国罗伯特-科赫研究所（Robert Koch Institute）于 2021 年实施了淋球菌耐药性监测（Go-Surv-AMR），以获取德国分离的淋病奈瑟菌的分子、表型和流行病学数据。在此，我们将介绍 Go-Surv-AMR 的结构和目标。此外，我们还指出了 Go-Surv-AMR 改进淋病奈瑟菌综合基因组监测的未来方向。在这方面，我们讨论了当前和未来的测序方法及其应用所产生的信息。此外，我们还强调了结合表型和 WGS 数据监测德国淋病奈瑟菌 AMR 演变的重要性。未来几年，实施并不断开发技术和工具以改进淋病奈瑟菌的基因组监测将非常重要。
Integrated molecular, phenotypic and epidemiological surveillance of antimicrobial resistance in Neisseria gonorrhoeae in Germany
Numbers of infections with Neisseria gonorrhoeae are among the top three sexually transmitted infections (STI) worldwide. In addition, the emergence and spread of antimicrobial resistance (AMR) in Neisseria gonorrhoeae pose an important public-health issue. The integration of genomic, phenotypic and epidemiological data to monitor Neisseria gonorrhoeae fosters our understanding of the emergence and spread of AMR in Neisseria gonorrhoeae and helps to inform therapy guidelines and intervention strategies. Thus, the Gonococcal resistance surveillance (Go-Surv-AMR) was implemented at the Robert Koch Institute in Germany in 2021 to obtain molecular, phenotypic and epidemiological data on Neisseria gonorrhoeae isolated in Germany. Here, we describe the structure and aims of Go-Surv-AMR. Furthermore, we point out future directions of Go-Surv-AMR to improve the integrated genomic surveillance of Neisseria gonorrhoeae. In this context we discuss current and prospective sequencing approaches and the information derived from their application. Moreover, we highlight the importance of combining phenotypic and WGS data to monitor the evolution of AMR in Neisseria gonorrhoeae in Germany. The implementation and constant development of techniques and tools to improve the genomic surveillance of Neisseria gonorrhoeae will be important in coming years.
期刊介绍：
Pathogen genome sequencing projects have provided a wealth of data that need to be set in context to pathogenicity and the outcome of infections. In addition, the interplay between a pathogen and its host cell has become increasingly important to understand and interfere with diseases caused by microbial pathogens. IJMM meets these needs by focussing on genome and proteome analyses, studies dealing with the molecular mechanisms of pathogenicity and the evolution of pathogenic agents, the interactions between pathogens and host cells ("cellular microbiology"), and molecular epidemiology. To help the reader keeping up with the rapidly evolving new findings in the field of medical microbiology, IJMM publishes original articles, case studies and topical, state-of-the-art mini-reviews in a well balanced fashion. All articles are strictly peer-reviewed. Important topics are reinforced by 2 special issues per year dedicated to a particular theme. Finally, at irregular intervals, current opinions on recent or future developments in medical microbiology are presented in an editorial section.
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